anticorps MPS-1, anticorps MPS1, anticorps S27, anticorps 3200001M24Rik, anticorps GB13072, anticorps DDBDRAFT_0203425, anticorps DDBDRAFT_0231065, anticorps DDB_0203425, anticorps DDB_0231065, anticorps mps-1, anticorps mps1, anticorps ribosomal protein S27, anticorps 40S ribosomal protein S27, anticorps ribosomal protein S27 pseudogene, anticorps Ribosomal protein S27, component of cytosolic 80S ribosome and 40S small subunit, anticorps component of 80S ribosome and 40S small subunit, anticorps ribosomal protein S27 L homeolog, anticorps RPS27, anticorps Rps27, anticorps LOC726295, anticorps RPS27P, anticorps rps27, anticorps rps27.L, anticorps rps-27
Sujet
Synonyms:MPS1 Background:Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of four RNA species and approximately 80 structurally distinct proteins. This gene encodes a member of the S27e family of ribosomal proteins and component of the 40S subunit. The encoded protein contains a C4-type zinc finger domain that can bind to zinc and may bind to nucleic acid. Studies in rat indicate that ribosomal protein S27 is located near ribosomal protein S18 in the 40S subunit and is covalently linked to translation initiation factor eIF3. Mutations in this gene have been identified in numerous melanoma patients and in at least one patient with Diamond-Blackfan anemia (DBA). Elevated expression of this gene has been observed in various human cancers. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.