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RNF4 anticorps

RNF4 Reactivité: Humain, Souris, Rat ELISA, IP Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN7118657
  • Antigène Voir toutes RNF4 Anticorps
    RNF4 (Ring Finger Protein 4 (RNF4))
    Reactivité
    Humain, Souris, Rat
    Hôte
    • 17
    • 2
    Lapin
    Clonalité
    • 18
    • 1
    Polyclonal
    Conjugué
    • 12
    • 3
    • 2
    • 2
    Cet anticorp RNF4 est non-conjugé
    Application
    • 10
    • 9
    • 4
    • 2
    • 1
    • 1
    ELISA, Immunoprecipitation (IP)
    Purification
    Immunogen affinity purified
    Pureté
    ≥95 % as determined by SDS-PAGE
    Immunogène
    ring finger protein 4
    Isotype
    IgG
    Top Product
    Discover our top product RNF4 Anticorps primaire
  • Indications d'application
    IP: 1:200-1:2000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
    Date de péremption
    12 months
  • Antigène
    RNF4 (Ring Finger Protein 4 (RNF4))
    Autre désignation
    RNF4 (RNF4 Produits)
    Synonymes
    anticorps SLX5, anticorps SNURF, anticorps AU018689, anticorps Gtrgeo8, anticorps ring finger protein 4, anticorps RNF4, anticorps Rnf4
    Sujet
    Synonyms:SNURF Background:E3 ubiquitin-protein ligase which binds polysumoylated chains covalently attached to proteins and mediates 'Lys-6'-, 'Lys-11'-, 'Lys-48'-and 'Lys-63'-linked polyubiquitination of those substrates and their subsequent targeting to the proteasome for degradation. Regulates the degradation of several proteins including PML and the transcriptional activator PEA3. Involved in chromosome alignment and spindle assembly, it regulates the kinetochore CENPH-CENPI-CENPK complex by targeting polysumoylated CENPI to proteasomal degradation. Regulates the cellular responses to hypoxia and heat shock through degradation of respectively EPAS1 and PARP1. Alternatively, it may also bind DNA/nucleosomes and have a more direct role in the regulation of transcription for instance enhancing basal transcription and steroid receptor-mediated transcriptional activation.
    ID gène
    6047
    UniProt
    P78317
    Pathways
    Intracellular Steroid Hormone Receptor Signaling Pathway
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