RNF41 anticorps

N° du produit ABIN7118659

Détail du produit anti-RNF41 anticorps

Antigène: RNF41 (Ring Finger Protein 41 (RNF41))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp RNF41 est non-conjugé

Application: Western Blotting (WB), ELISA

Purification: Immunogen affinity purified

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène: ring finger protein 41

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500-1:2000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Date de péremption: 12 months

Détails sur RNF41

Antigène: RNF41 (Ring Finger Protein 41 (RNF41))

Autre désignation: RNF41 (RNF41 Produits)

Synonymes: anticorps FLRF, anticorps NRDP1, anticorps 2210404G21Rik, anticorps 4930511A05Rik, anticorps 4933415P08Rik, anticorps D10Ertd722e, anticorps Nrdp1, anticorps wu:fi13f07, anticorps wu:fi25b06, anticorps zgc:55389, anticorps flrf, anticorps ring finger protein 41, anticorps ring finger protein 41 S homeolog, anticorps ring finger protein 41, E3 ubiquitin protein ligase, anticorps RNF41, anticorps Rnf41, anticorps rnf41, anticorps rnf41.S

Sujet: Synonyms:FLRF, NRDP1 Background:Acts as E3 ubiquitin-protein ligase and regulates the degradation of target proteins. Polyubiquitinates MYD88. Negatively regulates MYD88-dependent production of proinflammatory cytokines. Can promote TRIF-dependent production of type I interferon and inhibits infection with vesicular stomatitis virus(By similarity). Promotes also activation of TBK1 and IRF3. Involved in the ubiquitination of erythropoietin(EPO) and interleukin-3(IL-3) receptors. Thus, through maintaining basal levels of cytokine receptors, RNF41 is involved in the control of hematopoietic progenitor cell differentiation into myeloerythroid lineages(By similarity). Contributes to the maintenance of steady-state ERBB3 levels by mediating its growth factor-independent degradation. Involved in the degradation of the inhibitor of apoptosis BIRC6 and thus is an important regulator of cell death by promoting apoptosis. Acts also as a PARK2 modifier that accelerates its degradation, resulting in a reduction of PARK2 activity, influencing the balance of intracellular redox state. The RNF41-PARK2 pathway regulates autophagosome-lysosome fusion during late mitophagy. Mitophagy is a selective form of autophagy necessary for mitochondrial quality control(PubMed:24949970).

Poids moléculaire: 36 kDa

ID gène: 10193

UniProt: Q9H4P4

Pathways: SARS-CoV-2 Protein Interactome