RBM4 anticorps

N° du produit ABIN7118686

Détail du produit anti-RBM4 anticorps

Antigène: RBM4 (RNA Binding Motif Protein 4 (RBM4))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp RBM4 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP)

Purification: Immunogen affinity purified

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène: RNA binding motif protein 4

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500-1:2000, IP: 1:200-1:1000, IHC: 1:20-1:200, IF: 1:20-1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Date de péremption: 12 months

Détails sur RBM4

Antigène: RBM4 (RNA Binding Motif Protein 4 (RBM4))

Autre désignation: RBM4 (RBM4 Produits)

Synonymes: anticorps rbm4, anticorps rna-bp4, anticorps wu:fc31f07, anticorps wu:fc57h11, anticorps zgc:56302, anticorps LARK, anticorps RBM4A, anticorps ZCCHC21, anticorps ZCRB3A, anticorps 4921506I22Rik, anticorps Lark1, anticorps Mlark, anticorps Rbm4a, anticorps lark, anticorps Rbm4, anticorps RNA binding motif protein 4.1, anticorps RNA binding motif protein 4, anticorps RNA-binding protein 14, anticorps RNA-binding protein lark, anticorps rbm4.1, anticorps RBM4, anticorps LOC610648, anticorps Rbm4, anticorps LARK

Sujet: Synonyms:RBM4A Background:RNA-binding factor involved in multiple aspects of cellular processes like alternative splicing of pre-mRNA and translation regulation. Modulates alternative 5'-splice site and exon selection. Acts as a muscle cell differentiation-promoting factor. Activates exon skipping of the PTB pre-mRNA during muscle cell differentiation. Antagonizes the activity of the splicing factor PTBP1 to modulate muscle cell-specific exon selection of alpha tropomyosin. Binds to intronic pyrimidine-rich sequence of the TPM1 and MAPT pre-mRNAs. Required for the translational activation of PER1 mRNA in response to circadian clock. Binds directly to the 3'-UTR of the PER1 mRNA. Exerts a suppressive activity on Cap-dependent translation via binding to CU-rich responsive elements within the 3'UTR of mRNAs, a process increased under stress conditions or during myocytes differentiation. Recruits EIF4A1 to stimulate IRES-dependent translation initiation in respons to cellular stress. Associates to internal ribosome entry segment(IRES) in target mRNA species under stress conditions. Plays a role for miRNA-guided RNA cleavage and translation suppression by promoting association of AGO2-containing miRNPs with their cognate target mRNAs. Associates with miRNAs during muscle cell differentiation. Binds preferentially to 5'-CGCGCG[GCA]-3' motif in vitro.

Poids moléculaire: 40 kDa

ID gène: 5936

UniProt: Q9BWF3

Pathways: Regulation of Muscle Cell Differentiation, Photoperiodism