Tel:
+49 (0)241 95 163 153
Fax:
+49 (0)241 95 163 155
E-Mail:
orders@anticorps-enligne.fr

SETD2 anticorps

SETD2 Reactivité: Humain, Souris, Rat WB, IHC, ELISA, IF Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN7118991
  • Antigène Voir toutes SETD2 Anticorps
    SETD2 (SET Domain Containing 2 (SETD2))
    Reactivité
    • 28
    • 6
    • 5
    • 3
    • 2
    • 2
    Humain, Souris, Rat
    Hôte
    • 24
    • 3
    • 1
    Lapin
    Clonalité
    • 25
    • 3
    Polyclonal
    Conjugué
    • 16
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp SETD2 est non-conjugé
    Application
    • 12
    • 11
    • 11
    • 9
    • 6
    • 4
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)
    Purification
    Immunogen affinity purified
    Pureté
    ≥95 % as determined by SDS-PAGE
    Immunogène
    SET domain containing 2
    Isotype
    IgG
    Top Product
    Discover our top product SETD2 Anticorps primaire
  • Indications d'application
    WB: 1:500-1:2000, IHC: 1:20-1:200, IF: 1:10-1:100
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
    Date de péremption
    12 months
  • Antigène
    SETD2 (SET Domain Containing 2 (SETD2))
    Autre désignation
    SETD2 (SETD2 Produits)
    Synonymes
    anticorps Kif9, anticorps HBP231, anticorps HIF-1, anticorps HIP-1, anticorps HYPB, anticorps KMT3A, anticorps SET2, anticorps p231HBP, anticorps SET domain containing 2, anticorps Setd2, anticorps SETD2
    Sujet
    Synonyms:HIF1, HYPB, KIAA1732, KMT3A, SET2 Background:Histone methyltransferase that specifically trimethylates 'Lys-36' of histone H3(H3K36me3) using dimethylated 'Lys-36'(H3K36me2) as substrate. Represents the main enzyme generating H3K36me3, a specific tag for epigenetic transcriptional activation. Plays a role in chromatin structure modulation during elongation by coordinating recruitment of the FACT complex and by interacting with hyperphosphorylated POLR2A. Acts as a key regulator of DNA mismatch repair in G1 and early S phase by generating H3K36me3, a mark required to recruit MSH6 subunit of the MutS alpha complex: early recruitment of the MutS alpha complex to chromatin to be replicated allows a quick identification of mismatch DNA to initiate the mismatch repair reaction. H3K36me3 also plays an essential role in the maintenance of a heterochromatic state, by recruiting DNA methyltransferase DNMT3A. H3K36me3 is also enhanced in intron-containing genes, suggesting that SETD2 recruitment is enhanced by splicing and that splicing is coupled to recruitment of elongating RNA polymerase. Required during angiogenesis. Recruited to the promoters of adenovirus 12 E1A gene in case of infection, possibly leading to regulate its expression.
    Poids moléculaire
    287 kDa
    ID gène
    29072
    UniProt
    Q9BYW2
    Pathways
    Tube Formation
Vous êtes ici:
Support technique