SETD2 anticorps

N° du produit ABIN7118991

Détail du produit anti-SETD2 anticorps

Antigène: SETD2 (SET Domain Containing 2 (SETD2))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SETD2 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Purification: Immunogen affinity purified

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène: SET domain containing 2

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500-1:2000, IHC: 1:20-1:200, IF: 1:10-1:100

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Date de péremption: 12 months

Détails sur SETD2

Antigène: SETD2 (SET Domain Containing 2 (SETD2))

Autre désignation: SETD2 (SETD2 Produits)

Synonymes: anticorps Kif9, anticorps HBP231, anticorps HIF-1, anticorps HIP-1, anticorps HYPB, anticorps KMT3A, anticorps SET2, anticorps p231HBP, anticorps SET domain containing 2, anticorps Setd2, anticorps SETD2

Sujet: Synonyms:HIF1, HYPB, KIAA1732, KMT3A, SET2 Background:Histone methyltransferase that specifically trimethylates 'Lys-36' of histone H3(H3K36me3) using dimethylated 'Lys-36'(H3K36me2) as substrate. Represents the main enzyme generating H3K36me3, a specific tag for epigenetic transcriptional activation. Plays a role in chromatin structure modulation during elongation by coordinating recruitment of the FACT complex and by interacting with hyperphosphorylated POLR2A. Acts as a key regulator of DNA mismatch repair in G1 and early S phase by generating H3K36me3, a mark required to recruit MSH6 subunit of the MutS alpha complex: early recruitment of the MutS alpha complex to chromatin to be replicated allows a quick identification of mismatch DNA to initiate the mismatch repair reaction. H3K36me3 also plays an essential role in the maintenance of a heterochromatic state, by recruiting DNA methyltransferase DNMT3A. H3K36me3 is also enhanced in intron-containing genes, suggesting that SETD2 recruitment is enhanced by splicing and that splicing is coupled to recruitment of elongating RNA polymerase. Required during angiogenesis. Recruited to the promoters of adenovirus 12 E1A gene in case of infection, possibly leading to regulate its expression.

Poids moléculaire: 287 kDa

ID gène: 29072

UniProt: Q9BYW2

Pathways: Tube Formation