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SH2B1 anticorps

SH2B1 Reactivité: Humain WB, IHC, ELISA, IF, IP Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN7119013
  • Antigène Voir toutes SH2B1 Anticorps
    SH2B1 (SH2B Adaptor Protein 1 (SH2B1))
    Reactivité
    • 39
    • 8
    • 7
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 33
    • 3
    • 2
    • 2
    Lapin
    Clonalité
    • 39
    • 1
    Polyclonal
    Conjugué
    • 23
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp SH2B1 est non-conjugé
    Application
    • 30
    • 16
    • 7
    • 6
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF), Immunoprecipitation (IP)
    Purification
    Immunogen affinity purified
    Pureté
    ≥95 % as determined by SDS-PAGE
    Immunogène
    SH2B adaptor protein 1
    Isotype
    IgG
    Top Product
    Discover our top product SH2B1 Anticorps primaire
  • Indications d'application
    WB: 1:200-1:2000, IP: 1:200-1:2000, IHC: 1:20-1:200, IF: 1:20-1:200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
    Date de péremption
    12 months
  • Antigène
    SH2B1 (SH2B Adaptor Protein 1 (SH2B1))
    Autre désignation
    SH2B1 (SH2B1 Produits)
    Synonymes
    anticorps zgc:158474, anticorps SH2B3, anticorps PSM, anticorps SH2B, anticorps AI425885, anticorps C530001K22Rik, anticorps Irip, anticorps SH2-B, anticorps SH2-Bb, anticorps Sh2bpsm1, anticorps mKIAA1299, anticorps Sh2-b, anticorps Sh2b, anticorps SH2B adaptor protein 1, anticorps SH2B1, anticorps sh2b1, anticorps Sh2b1
    Sujet
    Synonyms:KIAA1299, SH2B Background:Adapter protein for several members of the tyrosine kinase receptor family. Involved in multiple signaling pathways mediated by Janus kinase(JAK) and receptor tyrosine kinases, including the receptors of insulin(INS), insulin-like growth factor I(IGF1), nerve growth factor(NGF), brain-derived neurotrophic factor(BDNF), glial cell line-derived neurotrophic factor(GDNF), platelet-derived growth factor(PDGF) and fibroblast growth factors(FGFs). In growth hormone(GH) signaling, autophosphorylated('Tyr-813') JAK2 recruits SH2B1, which in turn is phosphorylated by JAK2 on tyrosine residues. These phosphotyrosines form potential binding sites for other signaling proteins. GH also promotes serine/threonine phosphorylation of SH2B1 and these phosphorylated residues may serve to recruit other proteins to the GHR-JAK2-SH2B1 complexes, such as RAC1. In leptin(LEP) signaling, binds to and potentiates the activation of JAK2 by globally enhancing downstream pathways. In response to leptin, binds simultaneously to both, JAK2 and IRS1 or IRS2, thus mediating formation of a complex of JAK2, SH2B1 and IRS1 or IRS2. Mediates tyrosine phosphorylation of IRS1 and IRS2, resulting in activation of the PI 3-kinase pathway. Acts as positive regulator of NGF-mediated activation of the Akt/Forkhead pathway, prolongs NGF-induced phosphorylation of AKT1 on 'Ser-473' and AKT1 enzymatic activity. Enhances the kinase activity of the cytokine receptor-associated tyrosine kinase JAK2 and of other receptor tyrosine kinases, such as FGFR3 and NTRK1. For JAK2, the mechanism seems to involve dimerization of both, SH2B1 and JAK2. Enhances RET phosphorylation and kinase activity. Isoforms seem to be differentially involved in IGF-I and PDGF-induced mitogenesis(By similarity).
    ID gène
    25970
    UniProt
    Q9NRF2
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