SNX27 anticorps

N° du produit ABIN7119360

Détail du produit anti-SNX27 anticorps

Antigène: SNX27 (Sorting Nexin 27 (SNX27))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SNX27 est non-conjugé

Application: ELISA, Western Blotting (WB), Immunohistochemistry (IHC)

Purification: Immunogen affinity purified

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène: sorting nexin family member 27

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500-1:2000, IHC: 1:20-1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Date de péremption: 12 months

Détails sur SNX27

Antigène: SNX27 (Sorting Nexin 27 (SNX27))

Autre désignation: SNX27 (SNX27 Produits)

Synonymes: anticorps MRT1, anticorps MY014, anticorps 5730552M22Rik, anticorps ESTM45, anticorps ESTM47, anticorps R75405, anticorps mKIAA0488, anticorps Mrt1, anticorps sorting nexin family member 27, anticorps SNX27, anticorps Snx27

Sujet: Synonyms:KIAA0488 Background:Involved in the retrograde transport from endosome to plasma membrane, a trafficking pathway that promotes the recycling of internalized transmembrane proteins. Following internalization, endocytosed transmembrane proteins are delivered to early endosomes and recycled to the plasma membrane instead of being degraded in lysosomes. SNX27 specifically binds and directs sorting of a subset of transmembrane proteins containing a PDZ-binding motif at the C-terminus: following interaction with target transmembrane proteins, associates with the retromer complex, preventing entry into the lysosomal pathway, and promotes retromer-tubule based plasma membrane recycling. SNX27 also binds with the WASH complex. Interacts with membranes containing phosphatidylinositol-3-phosphate(PtdIns(3P)). May participate in establishment of natural killer cell polarity. Recruits CYTIP to early endosomes.

Poids moléculaire: 52-60 kDa

ID gène: 81609

UniProt: Q96L92