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SNX5 anticorps

SNX5 Reactivité: Humain, Souris, Rat WB, ELISA, IHC, IP Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN7119364
  • Antigène Voir toutes SNX5 Anticorps
    SNX5 (Sorting Nexin 5 (SNX5))
    Reactivité
    • 40
    • 13
    • 11
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    Humain, Souris, Rat
    Hôte
    • 38
    • 2
    Lapin
    Clonalité
    • 40
    Polyclonal
    Conjugué
    • 15
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp SNX5 est non-conjugé
    Application
    • 29
    • 13
    • 13
    • 9
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunoprecipitation (IP)
    Purification
    Immunogen affinity purified
    Pureté
    ≥95 % as determined by SDS-PAGE
    Immunogène
    sorting nexin 5
    Isotype
    IgG
    Top Product
    Discover our top product SNX5 Anticorps primaire
  • Indications d'application
    WB: 1:500-1:2000, IP: 1:200-1:1000, IHC: 1:20-1:200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
    Date de péremption
    12 months
  • Antigène
    SNX5 (Sorting Nexin 5 (SNX5))
    Autre désignation
    SNX5 (SNX5 Produits)
    Synonymes
    anticorps 0910001N05Rik, anticorps 1810032P22Rik, anticorps AU019504, anticorps D2Ertd52e, anticorps id:ibd5091, anticorps wu:fa66c10, anticorps wu:fi28h04, anticorps zgc:55769, anticorps SNX5, anticorps snx5, anticorps sorting nexin 5, anticorps sorting nexin 5 S homeolog, anticorps SNX5, anticorps Snx5, anticorps snx5.S, anticorps snx5
    Sujet
    Synonyms: Background:Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3-phosphate(PtdIns(3P)) or phosphatidylinositol 3,4-bisphosphate(PtdIns(3,4)P2)(PubMed:15561769). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network(TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier(ETC)(Probable). Does not have in vitro vesicle-to-membrane remodeling activity(PubMed:23085988). Involved in retrograde transport of lysosomal enzyme receptor IGF2R(PubMed:17148574, PubMed:18596235). May function as link between endosomal transport vesicles and dynactin(Probable). Plays a role in the internalization of EGFR after EGF stimulation(Probable). Involved in EGFR endosomal sorting and degradation, the function involves PIP5K1C isoform 3 and is retromer-independent(PubMed:23602387). Together with PIP5K1C isoform 3 facilitates HGS interaction with ubiquitinated EGFR, which initiates EGFR sorting to intraluminal vesicles(ILVs) of the multivesicular body for subsequent lysosomal degradation(Probable). Involved in E-cadherin sorting and degradation, inhibits PIP5K1C isoform 3-mediated E-cadherin degradation(PubMed:24610942). Plays a role in macropinocytosis(PubMed:18854019, PubMed:21048941).
    Poids moléculaire
    47 kDa
    ID gène
    27131
    UniProt
    Q9Y5X3
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