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SREBF chaperone anticorps

SCAP Reactivité: Humain, Souris WB, ELISA, IHC, IF Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN7119463
  • Antigène Voir toutes SREBF chaperone (SCAP) Anticorps
    SREBF chaperone (SCAP)
    Reactivité
    • 27
    • 17
    • 17
    • 1
    Humain, Souris
    Hôte
    • 40
    • 2
    Lapin
    Clonalité
    • 40
    • 2
    Polyclonal
    Conjugué
    • 16
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp SREBF chaperone est non-conjugé
    Application
    • 33
    • 13
    • 13
    • 11
    • 7
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)
    Purification
    Immunogen affinity purified
    Pureté
    ≥95 % as determined by SDS-PAGE
    Immunogène
    SREBF chaperone
    Isotype
    IgG
    Top Product
    Discover our top product SCAP Anticorps primaire
  • Indications d'application
    WB: 1:500-1:2000, IHC: 1:20-1:200, IF: 1:20-1:200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
    Date de péremption
    12 months
  • Antigène
    SREBF chaperone (SCAP)
    Autre désignation
    SCAP (SCAP Produits)
    Synonymes
    anticorps 9530044G19, anticorps mKIAA0199, anticorps SREBF chaperone, anticorps SREBF chaperone S homeolog, anticorps SCAP, anticorps Scap, anticorps scap.S
    Sujet
    Synonyms:KIAA0199 Background:Escort protein required for cholesterol as well as lipid homeostasis. Regulates export of the SCAP/SREBF complex from the ER upon low cholesterol. Formation of a ternary complex with INSIG at high sterol concentrations leads to masking of an ER-export signal in SCAP and retention of the complex in the ER. Low sterol concentrations trigger release of INSIG, a conformational change in the SSC domain of SCAP, unmasking of the ER export signal, recruitment into COPII-coated vesicles, transport to the Golgi complex, proteolytic cleavage of SREBF in the Golgi, release of the transcription factor fragment of SREBF from the membrane, its import into the nucleus and up-regulation of LDLR, INSIG1 and the mevalonate pathway(By similarity).SCAP has 4 isoforms with MW 140, 98, 96 and 85 kDa (refer to UniProt: Q12770).
    Poids moléculaire
    140 kDa,96 kDa
    ID gène
    22937
    UniProt
    Q12770
    Pathways
    SARS-CoV-2 Protein Interactome
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