TSPAN12 anticorps

N° du produit ABIN7119860

Détail du produit anti-TSPAN12 anticorps

Antigène: TSPAN12 (Tetraspanin 12 (TSPAN12))

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TSPAN12 est non-conjugé

Application: Western Blotting (WB), ELISA

Purification: Immunogen affinity purified

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène: tetraspanin 12

Isotype: IgG

Information d'application

Indications d'application: WB: 1:200-1:2000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Date de péremption: 12 months

Détails sur TSPAN12

Antigène: TSPAN12 (Tetraspanin 12 (TSPAN12))

Autre désignation: TSPAN12 (TSPAN12 Produits)

Synonymes: anticorps tm4sf12, anticorps zgc:63880, anticorps EVR5, anticorps NET-2, anticorps NET2, anticorps TM4SF12, anticorps 9030619E17, anticorps AI426782, anticorps AI663988, anticorps AW111457, anticorps Tm4sf12, anticorps tetraspanin-7, anticorps tetraspanin 12, anticorps LOC412465, anticorps TSPAN12, anticorps tspan12, anticorps Tspan12

Sujet: Synonyms:NET 2, NET2, Tetraspan NET 2, tetraspanin 12, TM4SF12, Tspan 12, TSPAN12 Background:Regulator of cell surface receptor signal transduction. Plays a central role in retinal vascularization by regulating norrin(NDP) signal transduction. Acts in concert with norrin(NDP) to promote FZD4 multimerization and subsequent activation of FZD4, leading to promote accumulation of beta-catenin(CTNNB1) and stimulate LEF/TCF-mediated transcriptional programs. Suprisingly, it only activate the norrin(NDP)-dependent activation of FZD4, while it does not activate the Wnt-dependent activation of FZD4, suggesting the existence of a Wnt-independent signaling that also promote accumulation the beta-catenin(CTNNB1)(By similarity). Acts as a regulator of membrane proteinases such as ADAM10 and MMP14/MT1-MMP. Activates ADAM10-dependent cleavage activity of amyloid precursor protein(APP). Activates MMP14/MT1-MMP-dependent cleavage activity.

Poids moléculaire: 28 kDa

ID gène: 23554

UniProt: O95859