THO Complex 5 anticorps

N° du produit ABIN7119927

Détail du produit anti-THO Complex 5 anticorps

Antigène: THO Complex 5 (THOC5)

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp THO Complex 5 est non-conjugé

Application: ELISA, Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunofluorescence (IF)

Purification: Immunogen affinity purified

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène: THO complex 5

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500-1:2000, IHC: 1:20-1:200, IF: 1:20-1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Date de péremption: 12 months

Détails sur THO Complex 5

Antigène: THO Complex 5 (THOC5)

Autre désignation: THOC5 (THOC5 Produits)

Synonymes: anticorps C22orf19, anticorps Fmip, anticorps PK1.3, anticorps fSAP79, anticorps 1700060C24Rik, anticorps A430085L24Rik, anticorps Sgk2, anticorps fc54b09, anticorps wu:fc54b09, anticorps zgc:56190, anticorps zgc:76912, anticorps THOC5, anticorps fmip, anticorps thoc5, anticorps thoc5-a, anticorps thoc5-b, anticorps THO complex 5, anticorps THO complex 5 S homeolog, anticorps THO complex 5 L homeolog, anticorps THOC5, anticorps Thoc5, anticorps thoc5, anticorps thoc5.S, anticorps thoc5.L

Sujet: Synonyms:C22orf19, KIAA0983 Background:Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex(EJC) and is recruited in a splicing-and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus(KSHV) intronless mRNAs and infectious virus production. THOC5 in conjunction with ALYREF/THOC4 functions in NXF1-NXT1 mediated nuclear export of HSP70 mRNA, both proteins enhance the RNA binding activity of NXF1 and are required for NXF1 localization to the nuclear rim. Involved in transcription elongation and genome stability. Involved in alternative polyadenylation site choice by recruiting CPSF6 to 5' region of target genes, probably mediates association of the TREX and CFIm complexes. Regulates the expression of myeloid transcription factors CEBPA, CEBPB and GAB2 by enhancing the levels of phosphatidylinositol 3,4,5-trisphosphate. May be involved in the differentiation of granulocytes and adipocytes. Essential for hematopoietic primitive cell survival and plays an integral role in monocytic development.

Poids moléculaire: 79 kDa

ID gène: 8563

UniProt: Q13769