anticorps LTRPC5, anticorps MTR1, anticorps 9430099A16Rik, anticorps LTrpC-5, anticorps Ltrpc5, anticorps Mtr1, anticorps transient receptor potential cation channel subfamily M member 5, anticorps transient receptor potential cation channel, subfamily M, member 5, anticorps TRPM5, anticorps Trpm5, anticorps trpm5
Sujet
Synonyms:LTrpC 5, LTRPC5, MTR1, TRPM5 Background:Voltage-modulated Ca(2+)-activated, monovalent cation channel(VCAM) that mediates a transient membrane depolarization and plays a central role in taste transduction. Monovalent-specific, non-selective cation channel that mediates the transport of Na(+), K(+) and Cs(+) ions equally well. Activated directly by increases in intracellular Ca(2+), but is impermeable to it. Gating is voltage-dependent and displays rapid activation and deactivation kinetics upon channel stimulation even during sustained elevations in Ca(2+). Also activated by a fast intracellular Ca(2+) increase in response to inositol 1,4,5-triphosphate-producing receptor agonists. The channel is blocked by extracellular acidification. External acidification has 2 effects, a fast reversible block of the current and a slower irreversible enhancement of current inactivation. Is a highly temperature-sensitive, heat activated channel showing a steep increase of inward currents at temperatures between 15 and 35 degrees Celsius. Heat activation is due to a shift of the voltage-dependent activation curve to negative potentials. Activated by arachidonic acid in vitro. May be involved in perception of bitter, sweet and umami tastes. May also be involved in sensing semiochemicals.