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USP20 anticorps

USP20 Reactivité: Humain, Souris, Rat ELISA, WB, IHC, IP Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN7120505
  • Antigène Voir toutes USP20 Anticorps
    USP20 (Ubiquitin Specific Peptidase 20 (USP20))
    Reactivité
    • 41
    • 11
    • 5
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    Humain, Souris, Rat
    Hôte
    • 37
    • 4
    • 1
    Lapin
    Clonalité
    • 41
    • 1
    Polyclonal
    Conjugué
    • 21
    • 5
    • 4
    • 4
    • 4
    • 4
    Cet anticorp USP20 est non-conjugé
    Application
    • 29
    • 25
    • 17
    • 4
    • 3
    ELISA, Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP)
    Purification
    Immunogen affinity purified
    Pureté
    ≥95 % as determined by SDS-PAGE
    Immunogène
    ubiquitin specific peptidase 20
    Isotype
    IgG
    Top Product
    Discover our top product USP20 Anticorps primaire
  • Indications d'application
    WB: 1:200-1:2000, IHC: 1:20-1:200,IP: 1:200-1:2000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
    Date de péremption
    12 months
  • Antigène
    USP20 (Ubiquitin Specific Peptidase 20 (USP20))
    Autre désignation
    USP20 (USP20 Produits)
    Synonymes
    anticorps USP20, anticorps vdu2, anticorps lsfr3a, anticorps LSFR3A, anticorps VDU2, anticorps hVDU2, anticorps 1700055M05Rik, anticorps AI467231, anticorps Vdu2, anticorps im:7151955, anticorps zgc:63661, anticorps universal stress protein, anticorps ubiquitin specific peptidase 20, anticorps ubiquitin specific peptidase 20 L homeolog, anticorps RR_RS15875, anticorps USP20, anticorps usp20, anticorps Usp20, anticorps usp20.L
    Sujet
    Synonyms:Deubiquitinating enzyme 20, hVDU2, KIAA1003, LSFR3A, Ubiquitin thiolesterase 20, USP20, VDU2 Background:Deubiquitinating enzyme involved in beta-2 adrenergic receptor(ADRB2) recycling. Acts as a regulator of G-protein coupled receptor(GPCR) signaling by mediating the deubiquitination beta-2 adrenergic receptor(ADRB2). Plays a central role in ADRB2 recycling and resensitization after prolonged agonist stimulation by constitutively binding ADRB2, mediating deubiquitination of ADRB2 and inhibiting lysosomal trafficking of ADRB2. Upon dissociation, it is probably transferred to the translocated beta-arrestins, possibly leading to beta-arrestins deubiquitination and disengagement from ADRB2. This suggests the existence of a dynamic exchange between the ADRB2 and beta-arrestins. Deubiquitinates DIO2, thereby regulating thyroid hormone regulation. Deubiquitinates HIF1A, leading to stabilize HIF1A and enhance HIF1A-mediated activity. Mediates deubiquitination of both 'Lys-48'-and 'Lys-63'-linked polyubiquitin chains.
    Poids moléculaire
    110 kDa
    ID gène
    10868
    UniProt
    Q9Y2K6
    Pathways
    Regulation of G-Protein Coupled Receptor Protein Signaling
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