VPS41 anticorps

N° du produit ABIN7120712

Détail du produit anti-VPS41 anticorps

Antigène: VPS41 (Vacuolar Protein Sorting 41 Homolog (VPS41))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp VPS41 est non-conjugé

Application: ELISA, Western Blotting (WB), Immunofluorescence (IF)

Purification: Immunogen affinity purified

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène: vacuolar protein sorting 41 homolog(S. cerevisiae)

Isotype: IgG

Information d'application

Indications d'application: WB: 1:200-1:1000, IF: 1:10-1:100

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Date de péremption: 12 months

Détails sur VPS41

Antigène: VPS41 (Vacuolar Protein Sorting 41 Homolog (VPS41))

Autre désignation: VPS41 (VPS41 Produits)

Synonymes: anticorps AI317346, anticorps Vam2, anticorps mVam2, anticorps HVPS41, anticorps HVSP41, anticorps hVps41p, anticorps RGD1560511, anticorps ATVAM2, anticorps ATVPS41, anticorps T23G18.5, anticorps T23G18_5, anticorps VACUOLAR PROTEIN SORTING 41, anticorps VAM2, anticorps ZIGZAG SUPPRESSOR 2, anticorps ZIP2, anticorps vacuolar protein sorting 41, anticorps Vacuolar assembly protein VPS41 homolog, anticorps VPS41, HOPS complex subunit, anticorps vacuolar protein sorting 41, anticorps vacuolar protein sorting 41, putative, anticorps Vacuolar protein sorting-associated protein 41 homolog, anticorps VPS41 HOPS complex subunit, anticorps Bm1_34430, anticorps VPS41, anticorps CNI02550, anticorps CC1G_08871, anticorps MCYG_00680, anticorps VDBG_03430, anticorps MGYG_01292, anticorps CGB_H3560C, anticorps vps-41, anticorps Vps41

Sujet: Synonyms:HVPS41, hVps41p, HVSP41, S53, VPS41 Background:Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act in part as a core component of the putative HOPS endosomal tethering complex is proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes(PubMed:23351085). Involved in homotypic vesicle fusions between late endosomes and in heterotypic fusions between late endosomes and lysosomes implicated in degradation of endocytosed cargo(PubMed:9159129, PubMed:23167963, PubMed:25445562, PubMed:25908847). Required for fusion of autophagosomes with lysosomes(PubMed:25783203). May link the HOPS complex to endosomal Rab7 via its association with RILP and to lysosomal membranes via its association with ARL8B, suggesting that these interactions may bring the compartments to close proximity for fusion(PubMed:25445562, PubMed:25908847). Involved in the direct trans-Golgi network to late endosomes transport of lysosomal membrane proteins independently of HOPS(PubMed:23322049). Involved in sorting to the regulated secretory pathway presumably implicating the AP-3 adaptor complex(By similarity). May play a role in HOPS-independent function in the regulated secretory pathway(PubMed:24210660).

Poids moléculaire: 70 kDa, 93 kDa

ID gène: 27072

UniProt: P49754