VPS26A anticorps

N° du produit ABIN7120721

Détail du produit anti-VPS26A anticorps

Antigène: VPS26A (Vacuolar Protein Sorting-Associated Protein 26A (VPS26A))

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp VPS26A est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Purification: Immunogen affinity purified

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène: vacuolar protein sorting 26 homolog A

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500-1:2000, IHC: 1:20-1:200, IF: 1:20-1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Date de péremption: 12 months

Détails sur VPS26A

Antigène: VPS26A (Vacuolar Protein Sorting-Associated Protein 26A (VPS26A))

Autre désignation: VPS26A (VPS26A Produits)

Synonymes: anticorps HB58, anticorps Hbeta58, anticorps PEP8A, anticorps VPS26, anticorps AA407240, anticorps Vps26, anticorps VPS26A, anticorps MNC6.7, anticorps MNC6_7, anticorps vacuolar protein sorting 26A, anticorps DKFZp459G2011, anticorps hb58, anticorps hbeta58, anticorps pep8a, anticorps vps26, anticorps vps26a, anticorps wu:fc67e06, anticorps zgc:56673, anticorps VPS26, retromer complex component A, anticorps VPS26 retromer complex component A, anticorps vacuolar protein sorting 26A, anticorps vacuolar protein sorting 26, anticorps vacuolar protein sorting homolog26, anticorps vacuolar protein sorting 26 homolog A (S. pombe) pseudogene, anticorps VPS26 retromer complex component A S homeolog, anticorps VPS26 retromer complex component A L homeolog, anticorps vacuolar protein sorting 26 homolog A (S. pombe), anticorps VPS26A, anticorps Vps26a, anticorps LOC692917, anticorps vpsh26, anticorps LOC100147400, anticorps vps26a.S, anticorps vps26a.L, anticorps vps26a

Sujet: Synonyms:FLJ12930, HB58, Hbeta58, hVPS26, PEP8A, Vesicle protein sorting 26A, VPS26, VPS26A Background:Acts as component of the retromer cargo-selective complex(CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network(TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX3-retromer mediates the retrograde endosome-to-TGN transport of WLS distinct from the SNX-BAR retromer pathway. The SNX27-retromer is believed to be involved in endosome-to-plasma membrane trafficking and recycling of a broad spectrum of cargo proteins(Probable). The CSC seems to act as recruitment hub for other proteins, such as the WASH complex and TBC1D5(Probable). Required for retrograde transport of lysosomal enzyme receptor IGF2R(PubMed:15078902, PubMed:15078903). Required to regulate transcytosis of the polymeric immunoglobulin receptor(pIgR-pIgA)(PubMed:15247922). Required for the endosomal localization of FAM21A(indicative for the WASH complex)(PubMed:22070227). Required for the endosomal localization of TBC1D5(PubMed:20923837). Mediates retromer cargo reognition of SORL1 and is involved in trafficking of SORL1 implicated in sorting and processing of APP(PubMed:22279231). Involved in retromer-independent lysosomal sorting of F2R(PubMed:16407403). Involved in recycling of ADRB2(PubMed:21602791). Enhances the affinity of SNX27 for PDZ-binding motifs in cargo proteins(By similarity).

Poids moléculaire: 38 kDa

ID gène: 9559

UniProt: O75436