YTHDC1 anticorps

N° du produit ABIN7120901

Détail du produit anti-YTHDC1 anticorps

Antigène: YTHDC1 (YTH Domain Containing 1 (YTHDC1))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp YTHDC1 est non-conjugé

Application: ELISA, Western Blotting (WB)

Purification: Immunogen affinity purified

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène: YTH domain containing 1

Isotype: IgG

Information d'application

Indications d'application: WB: 1:200-1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Date de péremption: 12 months

Détails sur YTHDC1

Antigène: YTHDC1 (YTH Domain Containing 1 (YTHDC1))

Autre désignation: YTHDC1 (YTHDC1 Produits)

Synonymes: anticorps C80342, anticorps mKIAA1966, anticorps A730098D12Rik, anticorps zgc:101592, anticorps MGC89461, anticorps MGC137509, anticorps DKFZp459L1228, anticorps YT521, anticorps YT521-B, anticorps Yt521, anticorps YTH domain containing 1, anticorps YTH domain containing 1 L homeolog, anticorps Ythdc1, anticorps YTHDC1, anticorps ythdc1, anticorps ythdc1.L

Sujet: Synonyms:KIAA1966, Putative splicing factor YT521, YT521, YT521 B, YTH domain containing 1, YTHDC1 Background:Regulator of alternative splicing that specifically recognizes and binds N6-methyladenosine(m6A)-containing RNAs(PubMed:26318451, PubMed:26876937, PubMed:25242552). M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in the efficiency of mRNA splicing, processing and stability(PubMed:26318451, PubMed:25242552). Acts as a key regulator of exon-inclusion or exon-skipping during alternative splicing via interaction with mRNA splicing factors SRSF3 and SRSF10(PubMed:26876937). Specifically binds m6A-containing mRNAs and promotes recruitment of SRSF3 to its mRNA-binding elements adjacent to m6A sites, leading to exon-inclusion during alternative splicing(PubMed:26876937). In contrast, interaction with SRSF3 prevents interaction with SRSF10, a splicing factor that promotes exon skipping: this prevents SRSF10 from binding to its mRNA-binding sites close to m6A-containing regions, leading to inhibit exon skipping during alternative splicing(PubMed:26876937). May also regulate alternative splice site selection(PubMed:20167602).

Poids moléculaire: 110 kDa

ID gène: 91746

UniProt: Q96MU7