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Mesothelin anticorps (AA 273-407) (Biotin)

MSLN Reactivité: Humain IHC (f) Hôte: Souris Monoclonal Biotin
N° du produit ABIN7126105
  • Antigène Voir toutes Mesothelin (MSLN) Anticorps
    Mesothelin (MSLN)
    Épitope
    • 16
    • 9
    • 6
    • 5
    • 5
    • 5
    • 5
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 273-407
    Reactivité
    • 93
    • 24
    • 5
    • 2
    • 2
    • 2
    • 1
    • 1
    Humain
    Hôte
    • 80
    • 24
    • 4
    • 1
    • 1
    Souris
    Clonalité
    • 79
    • 29
    • 2
    Monoclonal
    Conjugué
    • 67
    • 11
    • 8
    • 6
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp Mesothelin est conjugé à/à la Biotin
    Application
    • 67
    • 51
    • 24
    • 22
    • 12
    • 10
    • 9
    • 4
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Immunohistochemistry (Formalin-fixed Sections) (IHC (f))
    Specificité
    Mesothelin is a 40 kDa glycosyl-phosphatidylinositol-anchored glycoprotein cleaved from a 69 kDa precursor protein. Mesothelin immunoreactivity is high in cancers of the ovary (serous papillary, endometrioid and undifferentiated) and pancreas, with less frequent staining seen in adenocarcinomas of the endometrium, lung and stomach/esophagus. Mesothelin is one of the most sensitive markers for mesothelioma.
    Réactivité croisée (Details)
    Human, Mouse and Rat.
    Purification
    Antibody purified from Bioreactor Concentrate by Protein A/G and conjugated to Biotin.
    Immunogène
    Recombinant fragment (around aa 273-407) of human Mesothelin (MSLN) protein (exact sequence is proprietary)
    Isotype
    IgG2b
    Top Product
    Discover our top product MSLN Anticorps primaire
  • Indications d'application

    Positive Control: CAPAN-2 or HeLa cells. Lung Mesothelioma.

    Known Application: Immunohistochemistry (Formalin-fixed) (2-4 μg/mL for 30 minutes at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95 °C followed by cooling at RT for 20 minutes),Optimal dilution for a specific application should be determined.

    Restrictions
    For Research Use only
  • Concentration
    100 μg/mL
    Buffer
    Antibody purified from Bioreactor Concentrate by Protein A/G and conjugated to Biotin. Prepared in 10mM PBS with 0.05% BSA and 0.05% azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C,-80 °C
    Stockage commentaire
    Antibody with azide - store at 2 to 8 °C. Antibody is stable for 24 months. Non-hazardous. Also available WITHOUT BSA & azide at 1.0mg/ml.
    Date de péremption
    24 months
  • Antigène
    Mesothelin (MSLN)
    Autre désignation
    MSLN (MSLN Produits)
    Synonymes
    anticorps MPF, anticorps SMRP, anticorps MSLN, anticorps mesothelin, anticorps MSLN, anticorps Msln, anticorps LOC611363, anticorps LOC100524016
    Sujet
    CAK1, Megakaryocyte potentiating factor, Mesothelin, MSLN, SMR, SMRP,Mesothelin (Mesothelial Marker)
    Cellular localisation: Cell Surface and Secreted
    Poids moléculaire
    40kDa (Mature form), 69kDa (Precursor)
    ID gène
    10232, 408488
    UniProt
    Q13421
    Pathways
    EGFR Signaling Pathway, Positive Regulation of Peptide Hormone Secretion, Intracellular Steroid Hormone Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway, Carbohydrate Homeostasis, cAMP Metabolic Process, Regulation of G-Protein Coupled Receptor Protein Signaling, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process
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