Periostin anticorps (AA 193-326)

N° du produit ABIN7504149

Détail du produit anti-Periostin anticorps

Antigène: Periostin (POSTN)

Épitope: AA 193-326

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Periostin est non-conjugé

Application: Immunohistochemistry (Formalin-fixed Sections) (IHC (f))

Specificité: Periostin (PN), also designated osteoblast-specific factor 2 (OSF-2), is a disulfide linked protein originally isolated as a osteoblast-specific factor. Periostin is a secreted protein that binds heparin and functions as a ligand for i±Vi²3 and i±Vi²5 integrins. In preosteoblasts, Periostin acts as a cell adhesion molecule and plays a role in osteoblast recruitment, spreading and attachment. Periostin is mainly detected in lower gastrointestinal tract, aorta, stomach, placenta, uterus and breast tissues but is up-regulated in epithelial ovarian tumors and overexpressed in breast cancer. Expression of Periostin is increased by bone morphogenetic protein (BMP2) and transforming growth factor i² 1 (TGF i² 1). Periostin contains a typical signal sequence, followed by a cysteine-rich domain, a fourfold repeated domain, which shows homology with the insect protein fasciclin, and a C-terminal domain.

Réactivité croisée (Details): Human.

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogène: Recombinant fragment (around aa193-326) of human POSTN protein (exact sequence is proprietary)

Isotype: IgG2b

Information d'application

Indications d'application:

Positive Control: Human placenta, breast or colon tissue.

Known Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95 °C followed by cooling at RT for 20 minutes),Optimal dilution for a specific application should be determined.

Restrictions: For Research Use only

Stockage

Concentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA and 0.05 % azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-80 °C

Stockage commentaire: Antibody with azide - store at 2 to 8 °C. Antibody is stable for 24 months. Non-hazardous. Also available WITHOUT BSA & azide at 1.0mg/ml.

Date de péremption: 24 months

Détails sur Periostin

Antigène: Periostin (POSTN)

Autre désignation: POSTN (POSTN Produits)

Synonymes: anticorps fa99h07, anticorps pn, anticorps postn, anticorps wu:fa99h07, anticorps wu:fc70f09, anticorps zgc:153873, anticorps LOC100008945, anticorps osf-2, anticorps pdlpostn, anticorps periostin, anticorps OSF-2, anticorps OSF2, anticorps PDLPOSTN, anticorps PN, anticorps RP11-412K4.1, anticorps A630052E07Rik, anticorps AI747096, anticorps Osf2, anticorps PLF, anticorps peri, anticorps Plf, anticorps periostin, anticorps periostin, osteoblast specific factor b, anticorps periostin, osteoblast specific factor, anticorps POSTN, anticorps postnb, anticorps postn, anticorps Postn

Sujet: Fasciclin-I like, Osteoblast specific factor 2 (OSF2), PDLPOSTN, Periodontal ligament specific periostin, Periostin isoform thy2 / th4 / thy6 / thy8, Periostin osteoblast specific factor, PN, POSTN,Periostin (POSTN)
Cellular localisation: Secreted > extracellular space > extracellular matrix.

Poids moléculaire: 84/74kDa (Periostin), 90kDa (secreted glycoprotein)

ID gène: 10631, 136348, 721018

UniProt: Q15063