Reelin anticorps (AA 1796-2115)

N° du produit ABIN7126322

Détail du produit anti-Reelin anticorps

Antigène: Reelin (RELN)

Épitope: AA 1796-2115

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Reelin est non-conjugé

Application: Western Blotting (WB), Immunoprecipitation (IP), ELISA, Immunofluorescence (IF), Coating (Coat), Immunohistochemistry (Formalin-fixed Sections) (IHC (f))

Specificité: Reelin (or Reln) is a large glycoprotein that is secreted by Cajal-Retzius cells in the forebrain and by granule neurons in the cerebellum. Reelin was shown to be mutated in reeler mice, a mutation that is associated with widespread disruption of laminated regions of the brain, leading to impaired motor coordination, tremors and ataxia. Reelin protein expression is complex and changes throughout development. Reelin appears to function upstream of Dab1, in a signaling pathway that controls cell positioning in the developing brain, and is also thought to be a direct effector of the neurotrophin BDNF.

Réactivité croisée (Details): Human, Mouse and Rodent.

Purification: 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.

Immunogène: Recombinant fragment (around aa 1796-2115) of human RELN protein

Isotype: IgG2b

Information d'application

Indications d'application:

Known_Application: ELISA (For coating, order antibody without BSA), ,Immunoprecipitation (1-2 μg per 100-500 μg of total protein (1 mL of cell lysate)), ,Immunofluorescence (1-2 μg/mL), Western Blot (1-2 μg/mL), ,Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95 °C followed by cooling at RT for 20 minutes),Optimal dilution for a specific application should be determined.

Positive_Control: Human or mouse brain or CNS.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Prepared in 10 mM PBS, WITHOUT BSA and Azide.

Agent conservateur: Azide free

Stock: -20 °C,-80 °C

Stockage commentaire: Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.

Date de péremption: 24 months

Détails sur Reelin

Antigène: Reelin (RELN)

Autre désignation: RELN (RELN Produits)

Synonymes: anticorps LIS2, anticorps PRO1598, anticorps RL, anticorps reeler, anticorps rl, anticorps Reelen, anticorps Rl, anticorps reln, anticorps RELN, anticorps MGC172539, anticorps reelin, anticorps reelin L homeolog, anticorps RELN, anticorps Reln, anticorps reln, anticorps reln.L, anticorps LOC579060

Sujet: LIS2, PRO1598, Reeler, Reelin, RELN, RELN_HUMAN, RL,Reelin
Cellular localisation: Cytoplasm

Poids moléculaire: 387.5kDa

ID gène: 19699, 655654

UniProt: P78509

Pathways: Synaptic Membrane