GRAMD4 anticorps

N° du produit ABIN7126410

Détail du produit anti-GRAMD4 anticorps

Antigène: GRAMD4 (GRAM Domain Containing 4 (GRAMD4))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp GRAMD4 est non-conjugé

Application: Flow Cytometry (FACS), Immunofluorescence (IF)

Specificité: The gene encoding GRAMD4 (GRAM domain-containing protein 4) maps to human chromosome 22, which houses over 500 genes and is the second smallest human chromosome. GRAMD4, also designated death-inducing protein (DIP), is a 578 amino acid mitochondrial membrane protein that acts as an essential mediator of the p53-independent E2F-1 death pathway, which is frequently found to be deregulated in several types of cancers. Overexpression of GRAMD4 results in a strong apoptotic response involving caspase-3 activation and cleavage of poly(ADP-ribose)-polymerase. GRAMD4 is expressed in lung and in primary lung squamous cell carcinoma (LSCC) and shows upregulation in mitochondria by E2F1 after addition of 4-hydroxytamoxifen. This evidence suggests that GRAMD4 may be a potential target for cancer therapies.

Réactivité croisée (Details): Human. Predicted to react in Rat.

Purification: 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.

Immunogène: Recombinant full-length human GRAMD4 protein

Isotype: IgG1

Information d'application

Indications d'application:

Known_Application: Flow Cytometry (1-2 μg/million cells), Immunofluorescence (1-2 μg/mL), ,Optimal dilution for a specific application should be determined.

Positive_Control: Human liver, heart or fetal brain.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Prepared in 10 mM PBS, WITHOUT BSA and Azide.

Agent conservateur: Azide free

Stock: -20 °C,-80 °C

Stockage commentaire: Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.

Date de péremption: 24 months

Détails sur GRAMD4

Antigène: GRAMD4 (GRAM Domain Containing 4 (GRAMD4))

Autre désignation: GRAMD4 (GRAMD4 Produits)

Sujet: Death-inducing protein, GRAM domain-containing protein 4 (GRAMD4),GRAMD4 (Transcription Factor)
Cellular localisation: Mitochondrion membrane. Colocalizes with COX4I1.

Poids moléculaire: 66kDa

ID gène: 23151, 475150

UniProt: Q6IC98