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MBNL3 anticorps

MBNL3 Reactivité: Humain FACS Hôte: Souris Monoclonal unconjugated
N° du produit ABIN7126833
  • Antigène Voir toutes MBNL3 Anticorps
    MBNL3 (Muscleblind-Like Splicing Regulator 3 (MBNL3))
    Reactivité
    • 29
    • 2
    Humain
    Hôte
    • 29
    • 1
    Souris
    Clonalité
    • 30
    Monoclonal
    Conjugué
    • 11
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp MBNL3 est non-conjugé
    Application
    • 19
    • 17
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Flow Cytometry (FACS)
    Specificité
    Pre-mRNA splicing is a critical step in the posttranscriptional regulation of gene expression. Several protein complexes are involved in proper mRNA splicing and transport. The muscleblind proteins, MBNL1, MBNL2 and MBNL3, promote inclusion or exclusion of specific exons on different pre-mRNAs by antagonizing the activity of CUG-BP and ETR-3-like factors bound to distinct intronic sites. MBNL1 and 2, which associate with expanded CUG repeats in vitro, localize to the nuclear foci in both DM1 and DM2 (myotonic dystrophy types 1 and 2), suggesting that the nuclear accumulation of mutant RNA is pathogenic in DM1, therefore implicating MBNL1 and 2 in the pathogenesis of both disorders. MBNL3, a 354 amino acid protein, inhibits expression of muscle differentiation, opposite to the function of MBNL1, which functions as a promoter of muscle differentiation. MBNL3 shows strong expression in placenta.
    Réactivité croisée (Details)
    Human
    Purification
    1.0mg/ml of Ab purified from Bioreactor by Protein A/G.
    Immunogène
    Recombinant full-length human MBNL3 protein
    Isotype
    IgG2b
    Top Product
    Discover our top product MBNL3 Anticorps primaire
  • Indications d'application

    Known_Application: Flow Cytometry (1-2 μg/million cells), ,Optimal dilution for a specific application should be determined.

    Positive_Control: HeLa or MCF7 cells.

    Restrictions
    For Research Use only
  • Concentration
    1.0 mg/mL
    Buffer
    Prepared in 10 mM PBS, WITHOUT BSA and Azide.
    Agent conservateur
    Azide free
    Stock
    -20 °C,-80 °C
    Stockage commentaire
    Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.
    Date de péremption
    24 months
  • Antigène
    MBNL3 (Muscleblind-Like Splicing Regulator 3 (MBNL3))
    Autre désignation
    MBNL3 (MBNL3 Produits)
    Synonymes
    anticorps A530038J18Rik, anticorps AI661274, anticorps CHCR, anticorps E430034C16Rik, anticorps MBLX, anticorps MBLX39, anticorps MBXL, anticorps mbxl, anticorps RGD1565834, anticorps muscleblind like splicing regulator 3, anticorps muscleblind like splicing factor 3, anticorps Muscleblind-like protein 3-like, anticorps muscleblind-like splicing regulator 3, anticorps MBNL3, anticorps Mbnl3, anticorps mbnl3
    Sujet
    CHCR, Cys3His CCG1 required protein, MBLX, MBLX39, Muscleblind like protein 3, Muscleblind like splicing regulator 3, Muscleblind-like X-linked protein, Protein HCHCR, RP23-98P13.1,MBNL3
    Cellular localisation: Nucleus. Cytoplasm. Greater concentration in the nucleus. In both DM1 and DM2 patients, colocalizes with nuclear foci of retained expanded-repeat transcripts.
    Poids moléculaire
    39kDa
    ID gène
    55796
    UniProt
    Q9NUK0
    Pathways
    Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development
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