PARVG anticorps

N° du produit ABIN7126930

Détail du produit anti-PARVG anticorps

Antigène: PARVG (Parvin, gamma (PARVG))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp PARVG est non-conjugé

Application: Western Blotting (WB), Immunoprecipitation (IP)

Specificité: The parvin family, including α-parvin, β-parvin and γ-parvin, link integrins and associated proteins with intracellular pathways, which regulate actin cytoskeletal dynamics and cell survival. All three family members localize to focal adhesions and function in cell adhesion, spreading, motility and survival through interactions with partners, such as integrin-linked kinase (ILK), paxillin, α-actinin and testicular kinase 1. α-parvin is widely expressed, with highest levels detected in the skeletal muscle, heart, liver and kidney. A complex made up of α-parvin, ILK and the LIM protein PINCH-1 is critical for cell survival in a variety of cells, including certain cancer cells, kidney podocytes and cardiac myocytes. β-parvin links initial integrin signals to rapid actin reorganization, thereby playing a critical role in fibroblast migration. The ILK-γ-parvin complex is essential for the establishment of cell polarity required for leukocyte migration.

Réactivité croisée (Details): Human.

Purification: 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.

Immunogène: GST-tagged recombinant protein corresponding to human Gamma-parvin

Isotype: IgG1

Information d'application

Indications d'application:

Known_Application: Immunoprecipitation (1-2 μg per 100-500 μg of total protein (1 mL of cell lysate)), ,Western Blot (1-2 μg/mL), ,Optimal dilution for a specific application should be determined.

Positive_Control: Jurkat cell lysate.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Prepared in 10 mM PBS, WITHOUT BSA and Azide.

Agent conservateur: Azide free

Stock: -20 °C,-80 °C

Stockage commentaire: Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.

Date de péremption: 24 months

Détails sur PARVG

Antigène: PARVG (Parvin, gamma (PARVG))

Autre désignation: PARVG (PARVG Produits)

Sujet: Gamma parvin, PARVG,Gamma-parvin
Cellular localisation: Cytoplasm. Cell Surface.

Poids moléculaire: 37kDa

ID gène: 64098

UniProt: Q9HBI0