STAT5A anticorps

N° du produit ABIN7126986

Détail du produit anti-STAT5A anticorps

Antigène: STAT5A (Signal Transducer and Activator of Transcription 5A (STAT5A))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp STAT5A est non-conjugé

Application: Immunofluorescence (IF), Flow Cytometry (FACS)

Specificité: Signal transducer and activator of transcription 5A (Stat5a) and Stat5b, which share 96 % homology, undergo receptor tyrosine kinase or G protein-coupled receptor-dependent phosphorylation in response to cytokines or growth factors, and then form homo- or heterodimers that translocate to the nucleus, where they initiate transcription. Activation of Stat5a via IL-2, IL-3, IL-7/ GM-CSF, erythropoietin, thrombopoietin and growth hormones influences proliferation, differentiation and apoptosis in lymphohematopoietic cells. Phosphorylation of Stat5a at Ser127/Ser128 and Ser779 are contigent on ErbB-4- mediated activation of Stat5a. Activation of Stat5b via IL-2, IL-4, CSF-1 and growth hormones influences TCR signaling, apoptosis, adult mammary gland development and sexual dimorphism of liver gene expression. Stat5b is the major liver-expressed Stat5 form that has been shown to fuse with the retinoic acid receptor a gene in acute promyelocytic leukemias (APLL). Stat5a/b null mice have severely impaired lymphoid development and differentiation.

Réactivité croisée (Details): Human. Predicted to work with Mouse and Rat.

Purification: 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.

Immunogène: Protein domain of STAT5A

Isotype: IgG2

Information d'application

Indications d'application:

Known_Application: Flow Cytometry (1-2 μg/million cells), Immunofluorescence (1-2 μg/mL), ,Optimal dilution for a specific application should be determined.

Positive_Control: HeLa or Jurkat cells.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Prepared in 10 mM PBS, WITHOUT BSA and Azide.

Agent conservateur: Azide free

Stock: -20 °C,-80 °C

Stockage commentaire: Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.

Date de péremption: 24 months

Détails sur STAT5A

Antigène: STAT5A (Signal Transducer and Activator of Transcription 5A (STAT5A))

Autre désignation: STAT5A (STAT5A Produits)

Synonymes: anticorps MGF, anticorps STAT5, anticorps AA959963, anticorps Stat5, anticorps STAT5A/MGF, anticorps STATA5, anticorps STAT5A, anticorps stat5, anticorps stat5b, anticorps signal transducer and activator of transcription 5A, anticorps signal transducer and activator of transcription 5a, anticorps STAT5A, anticorps Stat5a, anticorps stat5a, anticorps LOC100348518, anticorps LOC100716811

Sujet: Signal transducer and activator of transcription 5A, Transcription factor STAT5A, Mammary gland factor (MGF),STAT5A
Cellular localisation: Cytoplasm. Nucleus. Translocated into the nucleus in response to phosphorylation.

Poids moléculaire: 64kDa

ID gène: 6776, 437058

UniProt: P42229

Pathways: Signalistation JAK/STAT, Signalisation RTK, Response to Growth Hormone Stimulus, C21-Steroid Hormone Metabolic Process, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, CXCR4-mediated Signaling Events, Activated T Cell Proliferation