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Recombinant ALIX anticorps

PDCD6IP Reactivité: Humain WB, ELISA, FACS Hôte: Lapin Monoclonal 7E9 unconjugated Recombinant Antibody
N° du produit ABIN7127335
  • Antigène Voir toutes ALIX (PDCD6IP) Anticorps
    ALIX (PDCD6IP) (Programmed Cell Death 6 Interacting Protein (PDCD6IP))
    Type d'anticorp
    Recombinant Antibody
    Reactivité
    • 75
    • 34
    • 32
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 64
    • 13
    • 1
    Lapin
    Clonalité
    • 59
    • 18
    Monoclonal
    Conjugué
    • 32
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    Cet anticorp ALIX est non-conjugé
    Application
    • 48
    • 26
    • 26
    • 20
    • 12
    • 12
    • 10
    • 6
    • 6
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB), ELISA, Flow Cytometry (FACS)
     Réactivité croisée
    Humain, Rat
    Purification
    Affinity-chromatography
    Immunogène
    A synthesized peptide derived from human ALIX
    Clone
    7E9
    Isotype
    IgG
    Top Product
    Discover our top product PDCD6IP Anticorps primaire
  • Indications d'application
    Recommended dilution: WB:1:500-1:5000, FC:1:20-1:200,
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C,-80 °C
    Stockage commentaire
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Antigène
    ALIX (PDCD6IP) (Programmed Cell Death 6 Interacting Protein (PDCD6IP))
    Autre désignation
    PDCD6IP (PDCD6IP Produits)
    Synonymes
    anticorps DDBDRAFT_0167145, anticorps DDBDRAFT_0185177, anticorps DDB_0167145, anticorps DDB_0185177, anticorps AIP1, anticorps ALIX, anticorps DRIP4, anticorps HP95, anticorps AI480591, anticorps AW544830, anticorps Aip1, anticorps Alix, anticorps C76364, anticorps Eig2, anticorps mKIAA1375, anticorps CG12876, anticorps DAIP1, anticorps Dmel\\CG12876, anticorps GB11744, anticorps RGD1561176, anticorps zgc:63638, anticorps wu:fb70d03, anticorps wu:fy65h02, anticorps PDCD6IP, anticorps aip1, anticorps alix, anticorps hp95, anticorps drip4, anticorps ALG-2 interacting protein X, anticorps programmed cell death 6 interacting protein, anticorps programmed cell death 6-interacting protein, anticorps Programmed cell death 6 interacting protein, anticorps programmed cell death 6 interacting protein L homeolog, anticorps alxA, anticorps PDCD6IP, anticorps Pdcd6ip, anticorps ALiX, anticorps LOC412662, anticorps pdcd6ip, anticorps Bm1_48390, anticorps pdcd6ip.L
    Sujet

    Background: Multifunctional protein involved in endocytosis, multivesicular body biogenesis, membrane repair, cytokinesis, apoptosis and maintenance of tight junction integrity. Class E VPS protein involved in concentration and sorting of cargo proteins of the multivesicular body (MVB) for incorporation into intralumenal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome. Binds to the phospholipid lysobisphosphatidic acid (LBPA) which is abundant in MVBs internal membranes. The MVB pathway requires the sequential function of ESCRT-O, -I,-II and -III complexes (PubMed:14739459). The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis (PubMed:17853893, PubMed:17556548). Adapter for a subset of ESCRT-III proteins, such as CHMP4, to function at distinct membranes. Required for completion of cytokinesis (PubMed:17853893, PubMed:17556548, PubMed:18641129). May play a role in the regulation of both apoptosis and cell proliferation. Regulates exosome biogenesis in concert with SDC1/4 and SDCBP (PubMed:22660413). By interacting with F-actin, PARD3 and TJP1 secures the proper assembly and positioning of actomyosin-tight junction complex at the apical sides of adjacent epithelial cells that defines a spatial membrane domain essential for the maintenance of epithelial cell polarity and barrier (By similarity).

    Aliases: Programmed cell death 6-interacting protein (PDCD6-interacting protein) (ALG-2-interacting protein 1) (ALG-2-interacting protein X) (Hp95), PDCD6IP, AIP1 ALIX KIAA1375

    UniProt
    Q8WUM4
    Pathways
    Signalisation p53, EGFR Signaling Pathway, Sensory Perception of Sound, Cellular Response to Molecule of Bacterial Origin, Tube Formation
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