Recombinant APC anticorps
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- Antigène Voir toutes APC Anticorps
- APC (Adenomatous Polyposis Coli (APC))
- Type d'anticorp
- Recombinant Antibody
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Reactivité
- Humain
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Hôte
- Lapin
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Clonalité
- Monoclonal
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Conjugué
- Cet anticorp APC est non-conjugé
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Application
- Western Blotting (WB), Immunohistochemistry (IHC), ELISA
- Réactivité croisée
- Humain, Rat
- Purification
- Affinity-chromatography
- Immunogène
- A synthesized peptide derived from human APC
- Clone
- 5F2
- Isotype
- IgG
- Top Product
- Discover our top product APC Anticorps primaire
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- Indications d'application
- Recommended dilution: WB:1:500-1:5000, IHC:1:50-1:200,
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C,-80 °C
- Stockage commentaire
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- Antigène
- APC (Adenomatous Polyposis Coli (APC))
- Autre désignation
- APC (APC Produits)
- Synonymes
- anticorps dp2, anticorps dp3, anticorps fap, anticorps fpc, anticorps xapc, anticorps dp2.5, anticorps AI047805, anticorps AU020952, anticorps AW124434, anticorps CC1, anticorps Min, anticorps mAPC, anticorps BTPS2, anticorps DP2, anticorps DP2.5, anticorps DP3, anticorps GS, anticorps PPP1R46, anticorps RATAPC, anticorps APC1, anticorps APC, WNT signaling pathway regulator, anticorps adenomatous polyposis coli, anticorps adenomatous polyposis coli protein, putative, anticorps adenomatosis polyposis coli, anticorps adenomatous polyposis coli L homeolog, anticorps APC, anticorps apc, anticorps Smp_139190, anticorps Apc, anticorps apc.L
- Sujet
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Background: Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization.
Aliases: Adenomatous polyposis coli protein (Protein APC) (Deleted in polyposis 2.5), APC, DP2.5
- UniProt
- P25054
- Pathways
- Signalisation WNT, Stem Cell Maintenance, Cell-Cell Junction Organization
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