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Recombinant BUB1 anticorps

BUB1 Reactivité: Humain WB, ELISA Hôte: Lapin Monoclonal 9C11 unconjugated Recombinant Antibody
N° du produit ABIN7127373
  • Antigène Voir toutes BUB1 Anticorps
    BUB1 (Budding Uninhibited By Benzimidazoles 1 Homolog (Yeast) (BUB1))
    Type d'anticorp
    Recombinant Antibody
    Reactivité
    • 70
    • 27
    • 7
    • 1
    Humain
    Hôte
    • 60
    • 11
    Lapin
    Clonalité
    • 61
    • 10
    Monoclonal
    Conjugué
    • 42
    • 4
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp BUB1 est non-conjugé
    Application
    • 54
    • 30
    • 17
    • 13
    • 13
    • 13
    • 10
    • 7
    • 6
    • 5
    • 3
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), ELISA
     Réactivité croisée
    Humain
    Purification
    Affinity-chromatography
    Immunogène
    A synthesized peptide derived from human Bub1
    Clone
    9C11
    Isotype
    IgG
    Top Product
    Discover our top product BUB1 Anticorps primaire
  • Indications d'application
    Recommended dilution: WB:1:500-1:5000,
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C,-80 °C
    Stockage commentaire
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Antigène
    BUB1 (Budding Uninhibited By Benzimidazoles 1 Homolog (Yeast) (BUB1))
    Autre désignation
    BUB1 (BUB1 Produits)
    Synonymes
    anticorps bub1a, anticorps bub1l, anticorps hbub1, anticorps xbub1, anticorps BUB1A, anticorps BUB1L, anticorps hBUB1, anticorps AL022991, anticorps Bub1a, anticorps C80208, anticorps D2Xrf87, anticorps BUB1 mitotic checkpoint serine/threonine kinase, anticorps BUB1, mitotic checkpoint serine/threonine kinase, anticorps BUB1, anticorps bub1, anticorps Bub1
    Sujet

    Background: Serine/threonine-protein kinase that performs 2 crucial functions during mitosis: it is essential for spindle-assembly checkpoint signaling and for correct chromosome alignment. Has a key role in the assembly of checkpoint proteins at the kinetochore, being required for the subsequent localization of CENPF, BUB1B, CENPE and MAD2L1. Required for the kinetochore localization of PLK1. Required for centromeric enrichment of AUKRB in prometaphase. Plays an important role in defining SGO1 localization and thereby affects sister chromatid cohesion. Acts as a substrate for anaphase-promoting complex or cyclosome (APC/C) in complex with its activator CDH1 (APC/C-Cdh1). Necessary for ensuring proper chromosome segregation and binding to BUB3 is essential for this function. Can regulate chromosome segregation in a kinetochore-independent manner. Can phosphorylate BUB3. The BUB1-BUB3 complex plays a role in the inhibition of APC/C when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. This complex can also phosphorylate MAD1L1. Kinase activity is essential for inhibition of APC/CCDC20 and for chromosome alignment but does not play a major role in the spindle-assembly checkpoint activity. Mediates cell death in response to chromosome missegregation and acts to suppress spontaneous tumorigenesis.

    Aliases: Mitotic checkpoint serine/threonine-protein kinase BUB1 (hBUB1) (EC 2.7.11.1) (BUB1A), BUB1, BUB1L

    UniProt
    O43683
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