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Recombinant IRAK4 anticorps

IRAK4 Reactivité: Humain WB, ELISA, FACS Hôte: Lapin Monoclonal 10H4 unconjugated Recombinant Antibody
N° du produit ABIN7127580
  • Antigène Voir toutes IRAK4 Anticorps
    IRAK4 (Interleukin-1 Receptor-Associated Kinase 4 (IRAK4))
    Type d'anticorp
    Recombinant Antibody
    Reactivité
    • 112
    • 64
    • 27
    • 15
    • 14
    • 12
    • 3
    • 2
    • 2
    • 2
    • 1
    Humain
    Hôte
    • 105
    • 12
    • 1
    Lapin
    Clonalité
    • 106
    • 12
    Monoclonal
    Conjugué
    • 48
    • 8
    • 7
    • 7
    • 6
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp IRAK4 est non-conjugé
    Application
    • 108
    • 49
    • 37
    • 26
    • 16
    • 14
    • 12
    • 8
    • 8
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), ELISA, Flow Cytometry (FACS)
     Réactivité croisée
    Humain
    Purification
    Affinity-chromatography
    Immunogène
    A synthesized peptide derived from human IRAK4
    Clone
    10H4
    Isotype
    IgG
    Top Product
    Discover our top product IRAK4 Anticorps primaire
  • Indications d'application
    Recommended dilution: WB:1:500-1:5000, FC:1:20-1:200,
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C,-80 °C
    Stockage commentaire
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Antigène
    IRAK4 (Interleukin-1 Receptor-Associated Kinase 4 (IRAK4))
    Autre désignation
    IRAK4 (IRAK4 Produits)
    Synonymes
    anticorps zgc:55553, anticorps IRAK4, anticorps ipd1, anticorps irak-4, anticorps ny-ran-64, anticorps ny-ren-64, anticorps ren64, anticorps irak4, anticorps IPD1, anticorps IRAK-4, anticorps NY-REN-64, anticorps REN64, anticorps 8430405M07Rik, anticorps 9330209D03Rik, anticorps interleukin 1 receptor associated kinase 4, anticorps interleukin-1 receptor-associated kinase 4, anticorps IRAK4, anticorps irak4, anticorps Irak4
    Sujet

    Background: Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. Involved in Toll-like receptor (TLR) and IL-1R signaling pathways (PubMed:17878374). Is rapidly recruited by MYD88 to the receptor-signaling complex upon TLR activation to form the Myddosome together with IRAK2. Phosphorylates initially IRAK1, thus stimulating the kinase activity and intensive autophosphorylation of IRAK1. Phosphorylates E3 ubiquitin ligases Pellino proteins (PELI1, PELI2 and PELI3) to promote pellino-mediated polyubiquitination of IRAK1. Then, the ubiquitin-binding domain of IKBKG/NEMO binds to polyubiquitinated IRAK1 bringing together the IRAK1-MAP3K7/TAK1-TRAF6 complex and the NEMO-IKKA-IKKB complex. In turn, MAP3K7/TAK1 activates IKKs (CHUK/IKKA and IKBKB/IKKB) leading to NF-kappa-B nuclear translocation and activation. Alternatively, phosphorylates TIRAP to promote its ubiquitination and subsequent degradation. Phosphorylates NCF1 and regulates NADPH oxidase activation after LPS stimulation suggesting a similar mechanism during microbial infections.

    Aliases: Interleukin-1 receptor-associated kinase 4 (IRAK-4) (EC 2.7.11.1) (Renal carcinoma antigen NY-REN-64), IRAK4

    UniProt
    Q9NWZ3
    Pathways
    Signalisation NF-kappaB, Signalisation TLR, Activation of Innate immune Response, Toll-Like Receptors Cascades
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