Recombinant PTEN anticorps (pSer380)

N° du produit ABIN7321442

Détail du produit anti-PTEN anticorps

Antigène: PTEN (Phosphatase and Tensin Homolog (PTEN))

Type d'anticorp: Recombinant Antibody

Épitope: pSer380

Reactivité: Humain

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp PTEN est non-conjugé

Application: Western Blotting (WB), ELISA

Réactivité croisée: Humain

Purification: Affinity-chromatography

Immunogène: A synthesized peptide derived from human Phospho-PTEN (S380)

Clone: 4D10

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: WB:1:500-1:5000,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur PTEN

Antigène: PTEN (Phosphatase and Tensin Homolog (PTEN))

Autre désignation: PTEN (PTEN Produits)

Synonymes: anticorps 10q23del, anticorps BZS, anticorps CWS1, anticorps DEC, anticorps GLM2, anticorps MHAM, anticorps MMAC1, anticorps PTEN1, anticorps TEP1, anticorps 2310035O07Rik, anticorps A130070J02Rik, anticorps AI463227, anticorps B430203M17Rik, anticorps Mmac, anticorps PTENP1, anticorps wu:fc52g04, anticorps zgc:73086, anticorps fa11a08, anticorps fb73f10, anticorps fc83f12, anticorps fd16b10, anticorps fk90e11, anticorps pten, anticorps si:bz1g13.4, anticorps wu:fa11a08, anticorps wu:fb73f10, anticorps wu:fc83f12, anticorps wu:fd16b10, anticorps wu:fk90e11, anticorps phosphatase and tensin homolog, anticorps phosphatase and tensin homolog L homeolog, anticorps phosphatase and tensin homolog A, anticorps phosphatase and tensin homolog B, anticorps PTEN, anticorps Pten, anticorps pten.L, anticorps ptena, anticorps ptenb

Sujet:

Background: Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine-phosphorylated proteins. Also acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-diphosphate, phosphatidylinositol 3-phosphate and inositol 1,3,4,5-tetrakisphosphate with order of substrate preference in vitro PtdIns(3,4,5)P3 > PtdIns(3,4)P2 > PtdIns3P > Ins(1,3,4,5)P4 (PubMed:26504226). The lipid phosphatase activity is critical for its tumor suppressor function. Antagonizes the PI3K-AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival. The unphosphorylated form cooperates with AIP1 to suppress AKT1 activation. Dephosphorylates tyrosine-phosphorylated focal adhesion kinase and inhibits cell migration and integrin-mediated cell spreading and focal adhesion formation. Plays a role as a key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation. May be a negative regulator of insulin signaling and glucose metabolism in adipose tissue. The nuclear monoubiquitinated form possesses greater apoptotic potential, whereas the cytoplasmic nonubiquitinated form induces less tumor suppressive ability. In motile cells, suppresses the formation of lateral pseudopods and thereby promotes cell polarization and directed movement.

Aliases: Phosphatidylinositol 3, 4, 5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN, Mutated in multiple advanced cancers 1, Phosphatase and tensin homolog, PTEN, MMAC1, TEP1

UniProt: P60484

Pathways: TCR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Inositol Metabolic Process, Synaptic Membrane, Regulation of Cell Size, Autophagy, Platelet-derived growth Factor Receptor Signaling, Signaling of Hepatocyte Growth Factor Receptor, BCR Signaling