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Recombinant Retinoblastoma 1 anticorps (pSer780)

RB1 Reactivité: Humain IHC, ELISA, IF, IP Hôte: Lapin Monoclonal 2E9 unconjugated Recombinant Antibody
N° du produit ABIN7127740
  • Antigène Voir toutes Retinoblastoma 1 (RB1) Anticorps
    Retinoblastoma 1 (RB1)
    Type d'anticorp
    Recombinant Antibody
    Épitope
    • 34
    • 26
    • 25
    • 23
    • 21
    • 21
    • 18
    • 15
    • 11
    • 11
    • 10
    • 6
    • 6
    • 6
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    pSer780
    Reactivité
    • 287
    • 120
    • 105
    • 6
    • 4
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 252
    • 37
    Lapin
    Clonalité
    • 248
    • 41
    Monoclonal
    Conjugué
    • 131
    • 17
    • 16
    • 16
    • 11
    • 10
    • 6
    • 6
    • 6
    • 6
    • 6
    • 6
    • 6
    • 6
    • 6
    • 6
    • 6
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp Retinoblastoma 1 est non-conjugé
    Application
    • 208
    • 116
    • 106
    • 80
    • 79
    • 38
    • 30
    • 28
    • 27
    • 21
    • 15
    • 8
    • 7
    • 6
    • 6
    • 6
    • 4
    • 2
    • 1
    Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF), Immunoprecipitation (IP)
     Réactivité croisée
    Humain
    Purification
    Affinity-chromatography
    Immunogène
    A synthesized peptide derived from human Phospho-RB1 (S780)
    Clone
    2E9
    Isotype
    IgG
    Top Product
    Discover our top product RB1 Anticorps primaire
  • Indications d'application
    Recommended dilution: IHC:1:50-1:200, IF:1:20-1:200, IP:1:200-1:1000,
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C,-80 °C
    Stockage commentaire
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Antigène
    Retinoblastoma 1 (RB1)
    Autre désignation
    RB1 (RB1 Produits)
    Synonymes
    anticorps OSRC, anticorps RB, anticorps p105-Rb, anticorps pRb, anticorps pp110, anticorps Rb, anticorps Rb-1, anticorps P105-RB, anticorps PP110, anticorps RB11, anticorps zgc:154147, anticorps RB transcriptional corepressor 1, anticorps RB transcriptional corepressor like 1, anticorps retinoblastoma 1, anticorps RB1, anticorps RBL1, anticorps Rb1, anticorps rb1
    Sujet

    Background: Key regulator of entry into cell division that acts as a tumor suppressor. Promotes G0-G1 transition when phosphorylated by CDK3/cyclin-C. Acts as a transcription repressor of E2F1 target genes. The underphosphorylated, active form of RB1 interacts with E2F1 and represses its transcription activity, leading to cell cycle arrest. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV39H1, KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Inhibits the intrinsic kinase activity of TAF1. Mediates transcriptional repression by SMARCA4/BRG1 by recruiting a histone deacetylase (HDAC) complex to the c-FOS promoter. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex (By similarity). In case of viral infections, interactions with SV40 large T antigen, HPV E7 protein or adenovirus E1A protein induce the disassembly of RB1-E2F1 complex thereby disrupting RB1's activity.

    Aliases: Retinoblastoma-associated protein, p105-Rb, pRb, Rb, pp110, RB1

    UniProt
    P06400
    Pathways
    Cycle Cellulaire, Intracellular Steroid Hormone Receptor Signaling Pathway, Mitotic G1-G1/S Phases, DNA Replication, Maintenance of Protein Location, Synthesis of DNA, Autophagy
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