Recombinant RNF2 anticorps

N° du produit ABIN7127796

Détail du produit anti-RNF2 anticorps

Antigène: RNF2 (Ring Finger Protein 2 (RNF2))

Type d'anticorp: Recombinant Antibody

Reactivité: Humain

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp RNF2 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Réactivité croisée: Humain

Purification: Affinity-chromatography

Immunogène: A synthesized peptide derived from human RNF20

Clone: 2H12

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: WB:1:500-1:5000, IHC:1:50-1:200, IF:1:20-1:200,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur RNF2

Antigène: RNF2 (Ring Finger Protein 2 (RNF2))

Autre désignation: RNF2 (RNF2 Produits)

Synonymes: anticorps BAP-1, anticorps BAP1, anticorps DING, anticorps HIPI3, anticorps RING1B, anticorps RING2, anticorps AI326319, anticorps AI450156, anticorps AU019207, anticorps Ring1B, anticorps dinG, anticorps fa19h05, anticorps ring1b, anticorps wu:fa19h05, anticorps wz4556, anticorps bap-1, anticorps bap1, anticorps ding, anticorps hipi3, anticorps ring2, anticorps ring finger protein 2, anticorps ring finger protein 2 L homeolog, anticorps RNF2, anticorps Rnf2, anticorps rnf2, anticorps rnf2.L

Sujet:

Background: Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation (H3K4me and H3K79me, respectively). It thereby plays a central role inb histone code and gene regulation. The RNF20/40 complex forms a H2B ubiquitin ligase complex in cooperation with the E2 enzyme UBE2A or UBE2B, reports about the cooperation with UBE2E1/UBCH are contradictory. Required for transcriptional activation of Hox genes. Recruited to the MDM2 promoter, probably by being recruited by p53/TP53, and thereby acts as a transcriptional coactivator. Mediates the polyubiquitination of isoform 2 of PA2G4 in cancer cells leading to its proteasome-mediated degradation.

Aliases: E3 ubiquitin-protein ligase BRE1A (BRE1-A) (hBRE1) (EC 2.3.2.27) (RING finger protein 20) (RING-type E3 ubiquitin transferase BRE1A), RNF20, BRE1A

UniProt: Q5VTR2