CYFIP2 anticorps

N° du produit ABIN7129118

Détail du produit anti-CYFIP2 anticorps

Antigène: CYFIP2 (Cytoplasmic FMR1 Interacting Protein 2 (CYFIP2))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CYFIP2 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Réactivité croisée: Humain, Souris

Purification: Antigen affinity purification

Immunogène: Fusion protein of Human CYFIP2

Isotype: IgG

Information d'application

Indications d'application: ELISA:1:2000-1:5000, WB:1:500-1:2000, IHC:1:50-1:200,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: -20 °C, pH 7.4 PBS, 0.05 % Sodium azide, 40 % Glycerol

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur CYFIP2

Antigène: CYFIP2 (Cytoplasmic FMR1 Interacting Protein 2 (CYFIP2))

Autre désignation: CYFIP2 (CYFIP2 Produits)

Synonymes: anticorps CYFIP2, anticorps pir121, anticorps PIR121, anticorps zgc:194528, anticorps 1500004I01Rik, anticorps 6430511D02Rik, anticorps AA930218, anticorps AU022376, anticorps Pir121, anticorps mKIAA1168, anticorps cytoplasmic FMR1 interacting protein 2, anticorps CYFIP2, anticorps cyfip2, anticorps Cyfip2

Sujet:

Background: CYFIP2 (Cytoplasmic FMR1-interacting protein 2, p53-inducible protein 121) is a 1,278 amino acid protein encoded by the human gene CYFIP2. CYFIP2 belongs to the CYFIP family and is involved in T-cell adhesion and p53-dependent induction of apoptosis. It interacts with FMR1, FXR1 and FXR2 and is a component of the WAVE1 complex composed of Abi-2, CYFIP2, C3orf10/HSPC300, NAP125 and WASF1/WAVE1. Upon binding to activated Rac 1, CYFIP2 causes the complex to dissociate, releasing activated WASF1. The CYFIP2 promoter contains a p53-responsive element that confers p53 binding as well as transcriptional activation of a heterologous reporter. Induced expression of CYFIP2 is sufficient for caspase activation and cellular apoptosis, reminiscent of p53 activation.

Aliases: CYFIP2 antibody, KIAA1168 antibody, PIR121Cytoplasmic FMR1-interacting protein 2 antibody, p53-inducible protein 121 antibody

UniProt: Q96F07

Pathways: Signalisation RTK, Apoptose, Positive Regulation of Endopeptidase Activity