IGSF6 anticorps

N° du produit ABIN7129823

Détail du produit anti-IGSF6 anticorps

Antigène: IGSF6 (Immunoglobulin Superfamily, Member 6 (IGSF6))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp IGSF6 est non-conjugé

Application: ELISA, Immunohistochemistry (IHC)

Réactivité croisée: Humain

Purification: Antigen affinity purification

Immunogène: Fusion protein of Human IGSF6

Isotype: IgG

Information d'application

Indications d'application: ELISA:1:1000-1:5000, IHC:1:5-1:20,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: -20 °C, pH 7.4 PBS, 0.05 % Sodium azide, 40 % Glycerol

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur IGSF6

Antigène: IGSF6 (Immunoglobulin Superfamily, Member 6 (IGSF6))

Autre désignation: IGSF6 (IGSF6 Produits)

Synonymes: anticorps IGSF6, anticorps DORA, anticorps immunoglobulin superfamily member 6, anticorps immunoglobulin superfamily, member 6, anticorps IGSF6, anticorps Igsf6

Sujet:

Background: IGSF6 (DORA), a novel member of the immunoglobulin superfamily (IGSF) from human and rat expressed in dendritic and myeloid cells. Using a probe from the open reading frame of the rat cDNA, we isolated a cosmid which contains the entire mouse gene. By comparative analysis and reverse transcriptase polymerase chain reaction, we defined the intron/exon structure and the mRNA of the mouse gene and, with respect to human BAC clones, the human gene. The genes span 10 kb (mouse) and 12 kb (human), with six exons arranged in a manner similar to other members of the IGSF. All intron/exon boundaries follow the GT-AG rule. Expression of the mouse Igsf6 gene is restricted to cells of the immune system, particularly macrophages. Northern blot revealed a single mRNA of 2.5 kb, in contrast to the human gene which is expressed as two mRNAs of 1 and 2.5 kb. The human and mouse genes were localized to a locus associated with inflammatory bowel disease. Analysis of the flanking regions of the Igsf6 gene revealed the presence of an unrelated gene, transcribed from the opposite strand of the DNA and oriented such that the Igsf6 gene is encoded entirely within an intron. An identical organization is seen in human.

Aliases: Donwregulated by activation gene antibody, DORA antibody, Down regulated by activation (immunoglobulin superfamily) antibody, IgSF6 antibody, IGSF6_HUMAN antibody, Immunoglobulin superfamily member 6 antibody, Protein DORA antibody

UniProt: O95976