HMGCR anticorps (AA 251-350)

N° du produit ABIN709196

Détail du produit anti-HMGCR anticorps

Antigène: HMGCR (3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR))

Épitope: AA 251-350

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp HMGCR est non-conjugé

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Réactivité croisée: Humain, Souris, Rat

Homologie: Dog,Cow,Pig,Rabbit

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human HMGCR

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Références pour anticorps anti-HMGCR (ABIN709196)

Lee, Cho, Lee, Lee, Kim, Lee: "Ethanol extract of Pinus koraiensis leaves containing lambertianic acid exerts anti-obesity and hypolipidemic effects by activating adenosine monophosphate-activated protein kinase (AMPK)." dans: BMC complementary and alternative medicine, Vol. 16, pp. 51, (2016) (PubMed).

Yu, Zeng, Lei, Xiao, Li, Yuan, Lin: "Effects of SIRT1 gene knock-out via activation of SREBP2 protein-mediated PI3K/AKT signaling on osteoarthritis in mice." dans: Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban, Vol. 36, Issue 5, pp. 683-690, (2016) (PubMed).

Kou, Han, Wang, Huang, He, Han, Zhou, Ye, Li: "Synergetic cholesterol-lowering effects of main alkaloids from Rhizoma Coptidis in HepG2 cells and hypercholesterolemia hamsters." dans: Life sciences, Vol. 151, pp. 50-60, (2016) (PubMed).

Wu, He, Wang, Xue, Ning, Zou, Ye, Li, Wang, Pang: "The antihypercholesterolemic effect of jatrorrhizine isolated from Rhizoma Coptidis." dans: Phytomedicine : international journal of phytotherapy and phytopharmacology, Vol. 21, Issue 11, pp. 1373-81, (2014) (PubMed).

Détails sur HMGCR

Antigène: HMGCR (3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR))

Autre désignation: HMGCR (HMGCR Produits)

Synonymes: anticorps HMGR, anticorps LDLCQ3, anticorps hmg-coa-r, anticorps HMG-CoAR, anticorps Red, anticorps 3H3M, anticorps BcDNA:LD15354, anticorps CG10367, anticorps Clb, anticorps DmHMG-CoAr, anticorps Dmel\\CG10367, anticorps HMGCR, anticorps HMGCR_Dm, anticorps HMGCoAR, anticorps HMGCoARr, anticorps HMGCoAr, anticorps HmG-CoAR, anticorps Hmg, anticorps bro1, anticorps bs32f05.y1, anticorps clb, anticorps hmgc, anticorps hmgcr, anticorps hmgrc, anticorps l(3)01152, anticorps l(3)04684, anticorps hmgcr2, anticorps im:6912716, anticorps zgc:110746, anticorps 3-hydroxy-3-methylglutaryl-CoA reductase, anticorps 3-hydroxy-3-methylglutaryl-CoA reductase L homeolog, anticorps 3-hydroxy-3-methylglutaryl-Coenzyme A reductase, anticorps HMG Coenzyme A reductase, anticorps 3-hydroxy-3-methylglutaryl-CoA reductase b, anticorps HMGCR, anticorps hmgcr.L, anticorps Hmgcr, anticorps hmgcrb

Sujet:

Synonyms: LDLCQ3, 3-hydroxy-3-methylglutaryl-coenzyme A reductase, HMG-CoA reductase, HMGCR

Background: Transmembrane glycoprotein that is the rate-limiting enzyme in cholesterol biosynthesis as well as in the biosynthesis of nonsterol isoprenoids that are essential for normal cell function including ubiquinone and geranylgeranyl proteins.

ID gène: 3156

UniProt: P04035

Pathways: AMPK Signaling, Negative Regulation of Hormone Secretion, Regulation of Lipid Metabolism by PPARalpha