TWIST1 anticorps

N° du produit ABIN7138095

Détail du produit anti-TWIST1 anticorps

Antigène: TWIST1 (Twist Homolog 1 (Drosophila) (TWIST1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TWIST1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Réactivité croisée: Humain, Souris, Rat

Purification: Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Immunogène: Peptide sequence around aa.18~22(S-N-S-E-E) derived from Human Twist1

Isotype: IgG

Information d'application

Indications d'application: WB:1:500-1:1000, IHC:1:50-1:200,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Supplied at 1.0 mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur TWIST1

Antigène: TWIST1 (Twist Homolog 1 (Drosophila) (TWIST1))

Autre désignation: TWIST1 (TWIST1 Produits)

Synonymes: anticorps scs, anticorps Xtwi, anticorps acs3, anticorps X-twi, anticorps bpes2, anticorps bpes3, anticorps twist, anticorps Xtwist, anticorps MGC69439, anticorps twist1, anticorps ACS3, anticorps BPES2, anticorps BPES3, anticorps CRS1, anticorps SCS, anticorps TWIST, anticorps bHLHa38, anticorps AA960487, anticorps M-Twist, anticorps Pde, anticorps Ska10, anticorps Ska, anticorps Twist, anticorps pdt, anticorps cTwist, anticorps Twist1b, anticorps twist-1, anticorps wu:fd04c01, anticorps zgc:101115, anticorps twist family bHLH transcription factor 1, anticorps twist family bHLH transcription factor 1 S homeolog, anticorps twist basic helix-loop-helix transcription factor 1, anticorps twist homolog 1 (Drosophila), anticorps twist family bHLH transcription factor 1a, anticorps TWIST1, anticorps twist1, anticorps twist1.S, anticorps Twist1, anticorps twist1a

Sujet:

Background:

Acts as a transcriptional regulator. Inhibits myogenesis by sequestrating E proteins, inhibiting trans-activation by MEF2, and inhibiting DNA-binding by MYOD1 through physical interaction. This interaction probably involves the basic domains of both proteins. Also represses expression of proinflammatory cytokines such as TNFA and IL1B. Regulates cranial suture patterning and fusion. Activates transcription as a heterodimer with E proteins. Regulates gene expression differentially, depending on dimer composition. Homodimers induce expression of FGFR2 and POSTN while heterodimers repress FGFR2 and POSTN expression and induce THBS1 expression. Heterodimerization is also required for osteoblast differentiation.

"Twist regulates cytokine gene expression through a negative feedback loop that represses NF-kappaB activity."Sosic D., Richardson J.A., Yu K., Ornitz D.M., Olson E.N.Cell 112:169-180(2003) 
"Mutations of the TWIST gene in the Saethre-Chotzen syndrome."el Ghouzzi V., le Merrer M., Perrin-Schmitt F., et al., Nat. Genet. 15:42-46(1997)

Aliases: ACS3 antibody; B-HLH DNA binding protein antibody; bHLHa38 antibody; BPES2 antibody; BPES3 antibody; Class A basic helix-loop-helix protein 38 antibody; CRS antibody; CRS1 antibody; CSO antibody; H-twist antibody; OTTHUMP00000116043 antibody; SCS antibody; Twist basic helix loop helix transcription factor 1 antibody; Twist family bHLH transcription factor 1 antibody; Twist homolog 1 (Drosophila) antibody; Twist homolog 1 antibody; TWIST homolog of drosophila antibody; Twist related protein 1 antibody; Twist-related protein 1 antibody; TWIST1 antibody; TWST1_HUMAN antibody

UniProt: Q15672

Pathways: Signalisation p53, Proton Transport, Tube Formation, Negative Regulation of Transporter Activity