Protein Tob1 (TOB1) (pSer164) anticorps

N° du produit ABIN7138445

Détail du produit

Antigène: Protein Tob1 (TOB1)

Épitope: pSer164

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Inconjugué

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Réactivité croisée: Humain, Souris, Rat

Purification: Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

Immunogène: Peptide sequence around phosphorylation site of Serine 164(A-V-S(p)-P-T) derived from Human TOB1.

Isotype: IgG

Information d'application

Indications d'application: WB:1:500-1:1000, IHC:1:50-1:100,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détail du antigène

Antigène: Protein Tob1 (TOB1)

Autre désignation: TOB1 (TOB1 Produits)

Synonymes: anticorps Tob, anticorps Trob, anticorps APRO5, anticorps APRO6, anticorps PIG49, anticorps TOB, anticorps TROB, anticorps TROB1, anticorps tob1, anticorps tob1l, anticorps wu:fb54d02, anticorps wu:fb98h12, anticorps wu:fd15f10, anticorps zgc:65837, anticorps transducer of ErbB-2.1, anticorps transducer of ERBB2, 1, anticorps transducer of ERBB2, 1a, anticorps transducer of ERBB2, 1 S homeolog, anticorps transducer of ERBB2, 1b, anticorps Tob1, anticorps TOB1, anticorps tob1a, anticorps tob1.S, anticorps tob1b

Sujet:

Background:

This gene encodes a member of the tob/btg1 family of anti-proliferative proteins that have the potential to regulate cell growth. When exogenously expressed, this protein supresses cell growth in tissue culture. The protein undergoes phophorylation by a serine/threonine kinase, 90 kDa ribosomal S6 kinase. Interactions of this protein with the v-erb-b2 erythroblastic leukemia viral oncogene homolog 2 gene product p185 interferes with growth suppression. This protein inhibits T cell proliferation and transcription of cytokines and cyclins. The protein interacts with both mothers against decapentaplegic Drosophila homolog 2 and 4 to enhance their DNA binding activity. This interaction inhibits interleukin 2 transcription in T cells.

Matsuda S., Oncogene 12:705-713(1996).
Ebert L., Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
Kalnine N., Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.

Aliases: TOB1 antibody, TOB antibody, TROB1 antibody, Protein Tob1 antibody, Transducer of erbB-2 1 antibody

UniProt: P50616