HNRNPK anticorps (pSer216)
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- Antigène Voir toutes HNRNPK Anticorps
- HNRNPK (Heterogeneous Nuclear Ribonucleoprotein K (HNRNPK))
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Épitope
- pSer216
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Reactivité
- Humain
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp HNRNPK est non-conjugé
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Application
- Western Blotting (WB), ELISA
- Réactivité croisée
- Humain, Souris, Rat
- Purification
- Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
- Immunogène
- Peptide sequence around phosphorylation site of serine 216 (S-E-S(p)-P-I) derived from Human hnRNP K.
- Isotype
- IgG
- Top Product
- Discover our top product HNRNPK Anticorps primaire
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- Indications d'application
- WB:1:500-1:3000,
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C,-80 °C
- Stockage commentaire
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- Antigène
- HNRNPK (Heterogeneous Nuclear Ribonucleoprotein K (HNRNPK))
- Autre désignation
- HNRNPK (HNRNPK Produits)
- Synonymes
- anticorps CSBP, anticorps HNRPK, anticorps TUNP, anticorps Csbp, anticorps Hnrpk, anticorps hnrpk, anticorps MGC75642, anticorps wu:fb37h02, anticorps wu:fi34c04, anticorps zgc:66162, anticorps KBBP, anticorps NOVA, anticorps heterogeneous nuclear ribonucleoprotein K, anticorps heterogeneous nuclear ribonucleoprotein K S homeolog, anticorps heterogeneous nuclear ribonucleoprotein k, anticorps HNRNPK, anticorps Hnrnpk, anticorps hnrnpk.S, anticorps hnrnpk, anticorps LOC5565718, anticorps CpipJ_CPIJ000130, anticorps NGK_p0004
- Sujet
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Background: One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single-stranded DNA. Plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of p53/TP53, playing a role in p21/CDKN1A and 14-3-3 sigma/SFN induction By similarity. As far as transcription repression is concerned, acts by interacting with long intergenic RNA p21 (lincRNA-p21), a non-coding RNA induced by p53/TP53. This interaction is necessary for the induction of apoptosis, but not cell cycle arrest.
Aliases: CSBP antibody, dC stretch binding protein antibody, FLJ41122 antibody, Heterogeneous nuclear ribonucleoprotein K antibody, hnRNP K antibody, HNRNPK antibody, HNRPK antibody, HNRPK_HUMAN antibody, Transformation up regulated nuclear protein antibody, Transformation up-regulated nuclear protein antibody, Transformation upregulated nuclear protein antibody, TUNP antibody
- UniProt
- P61978
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