FANCD2 anticorps (pSer222)
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- Antigène Voir toutes FANCD2 Anticorps
- FANCD2 (Fanconi Anemia, Complementation Group D2 (FANCD2))
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Épitope
- pSer222
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Reactivité
- Humain
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp FANCD2 est non-conjugé
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Application
- Western Blotting (WB), ELISA
- Réactivité croisée
- Humain, Souris, Rat
- Purification
- Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
- Immunogène
- Peptide sequence around phosphorylation site of serine 222 (G-D-S(p)-Q-H) derived from Human FANCD2.
- Isotype
- IgG
- Top Product
- Discover our top product FANCD2 Anticorps primaire
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- Indications d'application
- WB:1:500-1:1000,
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C,-80 °C
- Stockage commentaire
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- Antigène
- FANCD2 (Fanconi Anemia, Complementation Group D2 (FANCD2))
- Autre désignation
- FANCD2 (FANCD2 Produits)
- Synonymes
- anticorps FANCD2, anticorps CG17269, anticorps CG31192, anticorps CG31194, anticorps Dmel\\CG17269, anticorps dmFANCD2, anticorps xfancd2, anticorps FA-D2, anticorps FA4, anticorps FACD, anticorps FAD, anticorps FAD2, anticorps FANCD, anticorps 2410150O07Rik, anticorps AU015151, anticorps BB137857, anticorps Fanconi anemia complementation group D2, anticorps CG17269 gene product from transcript CG17269-RA, anticorps Fanconi anemia group D2 protein, anticorps Fanconi anemia, complementation group D2, anticorps Fanconi anemia complementation group D2 L homeolog, anticorps FANCD2, anticorps Fancd2, anticorps LOC100455970, anticorps fancd2, anticorps fancd2.L
- Sujet
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Background:
Required for maintenance of chromosomal stability. Promotes accurate and efficient pairing of homologs during meiosis. Involved in the repair of DNA double-strand breaks, both by homologous recombination and single-strand annealing. May participate in S phase and G2 phase checkpoint activation upon DNA damage. Plays a role in preventing breakage and loss of missegregating chromatin at the end of cell division, particularly after replication stress. Required for the targeting, or stabilization, of BLM to non-centromeric abnormal structures induced by replicative stress. Promotes BRCA2/FANCD1 loading onto damaged chromatin. May also be involved in B-cell immunoglobulin isotype switching.
Ho GP, Margossian S, Taniguchi T, D'Andrea AD (2006)Mol Cell Biol 26, 7005-15. Nakanishi K, et al. (2002)Nat Cell Biol 4, 913-20. Taniguchi T, et al. (2002) Cell 109, 459-72 .Aliases: DKFZp762A223 antibody, FA 4 antibody, FA D2 antibody, FA4 antibody, FAC D2 antibody, FACD 2 antibody, FACD antibody, FACD2 antibody, FACD2_HUMAN antibody, FAD antibody, FAD2 antibody, FANC D2 antibody, FANCD 2 antibody, FANCD antibody, FANCD2 antibody, FANCONI ANEMIA COMPLEMENTATION GROUP D antibody, Fanconi anemia complementation group D2 antibody, Fanconi anemia group D2 protein antibody, FANCONI PANCYTOPENIA TYPE 4 antibody, FLJ23826 antibody, OTTHUMP00000158853 antibody, OTTHUMP00000207925 antibody, Protein FACD2 antibody, Type 4 Fanconi pancytopenia antibody
- UniProt
- Q9BXW9
- Pathways
- Réparation de l'ADN
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