IGF2R anticorps (pSer2409)

N° du produit ABIN7138501

Détail du produit anti-IGF2R anticorps

Antigène: IGF2R (Insulin-Like Growth Factor 2 Receptor (IGF2R))

Épitope: pSer2409

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp IGF2R est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Réactivité croisée: Humain, Souris

Purification: Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

Immunogène: Peptide sequence around phosphorylation site of Serine 2409(Q-D-S(p)-E-D) derived from Human IGF2R.

Isotype: IgG

Information d'application

Indications d'application: WB:1:500-1:1000, IHC:1:50-1:100,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur IGF2R

Antigène: IGF2R (Insulin-Like Growth Factor 2 Receptor (IGF2R))

Autre désignation: IGF2R (IGF2R Produits)

Sujet:

Background:

Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex. This receptor also binds IGF2. Acts as a positive regulator of T-cell coactivation, by binding DPP4.

Morgan D.O., Nature 329:301-307(1987).
Oshima A., J. Biol. Chem. 263:2553-2562(1988).
Killian J.K., Mamm. Genome 10:74-77(1999)

Aliases: 300 kDa mannose 6 phosphate receptor antibody, 300 kDa mannose 6-phosphate receptor antibody, Cation independent mannose 6 phosphate receptor antibody, Cation-independent mannose-6-phosphate receptor antibody, CD222 antibody, CD222 antigen antibody, CI Man 6 P receptor antibody, CI Man-6-P receptor antibody, CI MPR antibody, CI-M6PR antibody, CI-MPR antibody, CIMPR antibody, IGF 2 receptor antibody, IGF 2R antibody, IGF II receptor antibody, IGF-II receptor antibody, IGF2 receptor antibody, Igf2r antibody, Insulin like growth factor 2 receptor antibody, Insulin like growth factor II receptor antibody, Insulin-like growth factor 2 receptor antibody, Insulin-like growth factor II receptor antibody, M6P R antibody, M6P/IGF2 receptor antibody, M6P/IGF2R antibody, M6PR antibody, mannose 6 phosphate receptor antibody, mannose 6 phosphate receptor, cation independent antibody, MPR 300 antibody, MPR300 antibody, MPRI antibody, MPRI_HUMAN antibody

UniProt: P11717