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HDAC4/HDAC5/HDAC9 anticorps (pSer220, pSer246, pSer259)

Reactivité: Humain WB, IHC, ELISA Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN7138509
  • Antigène Tous les produits HDAC4/HDAC5/HDAC9
    HDAC4/HDAC5/HDAC9 (HDAC4,HDAC5,HDAC9)
    Épitope
    • 9
    • 9
    • 8
    • 2
    • 1
    • 1
    • 1
    pSer220, pSer246, pSer259
    Reactivité
    • 20
    • 11
    • 1
    Humain
    Hôte
    • 20
    Lapin
    Clonalité
    • 20
    Polyclonal
    Conjugué
    • 6
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    Cet anticorp HDAC4/HDAC5/HDAC9 est non-conjugé
    Application
    • 6
    • 5
    • 5
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), ELISA
     Réactivité croisée
    Humain
    Purification
    Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
    Immunogène
    Peptide sequence around phosphorylation site of serine 246/259/220 (T-A-S(p)-EP) derived from Human HDAC4/HDAC5/HDAC9.
    Isotype
    IgG
  • Indications d'application
    WB:1:500-1:1000, IHC:1:50-1:100,
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Supplied at 1.0 mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C,-80 °C
    Stockage commentaire
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Antigène
    HDAC4/HDAC5/HDAC9 (HDAC4,HDAC5,HDAC9)
    Autre désignation
    HDAC4/HDAC5/HDAC9 (HDAC4/HDAC5/HDAC9 Produits)
    Synonymes
    anticorps AHO3, anticorps BDMR, anticorps HA6116, anticorps HD4, anticorps HDAC-4, anticorps HDAC-A, anticorps HDACA, anticorps histone deacetylase 4, anticorps HDAC4
    Sujet

    Background:

    Histone Deacetylases (HDACs) are a group of enzymes closely related to sirtuins. They catalyze the removal of acetyl groups from lysine residues in histones and non-histone proteins, resulting in transcriptional repression. In general,they do not act autonomously but as components of large multiprotein complexes, such as pRb-E2F and mSin3A, that mediate important transcription regulatory pathways. There are three classes of HDACs, classes 1, 2 and 4, which are closely related Zn2+-dependent enzymes. HDACs are ubiquitously expressed and they can exist in the nucleus or cytosol. Their subcellular localization is effected by protein-protein interactions (for example HDAC-14.3.3 complexes are retained in the cytosol) and by the class to which they belong (class 1 HDACs are predominantly nuclear whilst class 2 HDACs shuttle between the nucleus and cytosol). HDACs have a role in cell growth arrest, differentiation and death and this has led to substantial interest in HDAC inhibitors as possible antineoplastic agents.

    Cress, W.D. and Seto, E. (2000) J Cell Physiol 184, 1-16.
    Vigushin, D.M. and Coombes, R.C. (2004) Curr. Cancer Drug Targets 4, 205-218.
    Marmorstein, R. (2001) Cell Mol Life Sci 58, 693-703.
    Thiagalingam, S. et al. (2003) Ann. N.Y. Acad. Sci. 983, 84-100.

    Aliases: HD4/HD5/HD9

    UniProt
    P56524, Q9UQL6, Q9UKV0
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