PKM anticorps (pSer37)

N° du produit ABIN7138580

Détail du produit anti-PKM anticorps

Antigène: PKM (Pyruvate Kinase M1/2 (PKM))

Épitope: pSer37

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PKM est non-conjugé

Application: ELISA, Western Blotting (WB), Immunofluorescence (IF)

Réactivité croisée: Humain

Purification: Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

Immunogène: Peptide sequence around phosphorylation site of serine 37(I-D-S(p)-P-P) derived from Human PKM2.

Isotype: IgG

Information d'application

Indications d'application: WB:1:500-1:1000, IF:1:100-1:200,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Supplied at 1.0 mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur PKM

Antigène: PKM (Pyruvate Kinase M1/2 (PKM))

Autre désignation: PKM (PKM Produits)

Synonymes: anticorps CTHBP, anticorps OIP3, anticorps PK3, anticorps PKM2, anticorps TCB, anticorps THBP1, anticorps AA414905, anticorps AL024370, anticorps AL024424, anticorps Pk-2, anticorps Pk-3, anticorps Pk3, anticorps Pkm2, anticorps PKM12, anticorps CG7070, anticorps Dmel\\CG7070, anticorps PYK, anticorps Pyk, anticorps cb1029, anticorps fj33f03, anticorps pkm2, anticorps pkm2a, anticorps wu:fj33f03, anticorps MGC53388, anticorps PKM, anticorps PK-S, anticorps pk3, anticorps pkm2b, anticorps zgc:92037, anticorps pyruvate kinase M1/2, anticorps pyruvate kinase, muscle, anticorps Pyruvate kinase, anticorps pyruvate kinase M1/2a, anticorps pyruvate kinase PKM, anticorps pyruvate kinase (PK), anticorps pyruvate kinase, anticorps pyruvate kinase M1/2 S homeolog, anticorps pyruvate kinase M1/2b, anticorps PKM, anticorps Pkm, anticorps PyK, anticorps pkma, anticorps pkm, anticorps LOC710798, anticorps pyk, anticorps pk, anticorps LOC100534543, anticorps pkm.S, anticorps pkmb

Sujet:

Background:

Glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP. Stimulates POU5F1-mediated transcriptional activation. Plays a general role in caspase independent cell death of tumor cells. The ratio betwween the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production. The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival.

Aliases: PKM, PK3, OIP3, PK2

Pathways: L'effet Warburg