ATR anticorps (pSer428)

N° du produit ABIN7138618

Détail du produit anti-ATR anticorps

Antigène: ATR (ATR serine/threonine kinase (ATR))

Épitope: pSer428

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ATR est non-conjugé

Application: ELISA, Immunohistochemistry (IHC)

Réactivité croisée: Humain

Purification: Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

Immunogène: Peptide sequence around phosphorylation site of serine 428 (G-I-S(p)-P-K) derived from Human ATR.

Isotype: IgG

Information d'application

Indications d'application: IHC:1:50-1:100,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur ATR

Antigène: ATR (ATR serine/threonine kinase (ATR))

Autre désignation: ATR (ATR Produits)

Synonymes: anticorps FCTCS, anticorps FRP1, anticorps MEC1, anticorps SCKL, anticorps SCKL1, anticorps ATR serine/threonine kinase, anticorps ataxia telangiectasia and Rad3 related, anticorps ATR, anticorps Atr

Sujet:

Background: Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates BRCA1, CHEK1, MCM2, RAD17, RPA2, SMC1 and p53/TP53, which collectively inhibit DNA replication and mitosis and promote DNA repair, recombination and apoptosis. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at sites of DNA damage, thereby regulating DNA damage response mechanism. Required for FANCD2 ubiquitination. Critical for maintenance of fragile site stability and efficient regulation of centrosome duplication.

Aliases: Ataxia telangiectasia and Rad3 related antibody, Ataxia telangiectasia and Rad3-related protein antibody, ATR antibody, ATR_HUMAN antibody, FCTCS antibody, FRAP Related Protein 1 antibody, FRAP-related protein 1 antibody, FRP1 antibody, MEC1 antibody, MEC1 mitosis entry checkpoint 1 homolog antibody, Protein kinase ATR antibody, RAC3 antibody, Rad3 related protein antibody, SCKL antibody, SCKL1 antibody, Serine/threonine protein kinase ATR antibody, Serine/threonine-protein kinase ATR antibody

UniProt: Q13535

Pathways: Positive Regulation of Response to DNA Damage Stimulus