SMC1A anticorps (pSer957)
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- Antigène Voir toutes SMC1A Anticorps
- SMC1A (Structural Maintenance of Chromosomes 1A (SMC1A))
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Épitope
- pSer957
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Reactivité
- Humain
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp SMC1A est non-conjugé
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Application
- Western Blotting (WB), Immunohistochemistry (IHC), ELISA
- Réactivité croisée
- Humain, Souris
- Purification
- Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
- Immunogène
- Peptide sequence around phosphorylation site of serine 957 (G-S-S(p)-Q-G) derived from Human SMC1.
- Isotype
- IgG
- Top Product
- Discover our top product SMC1A Anticorps primaire
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- Indications d'application
- WB:1:500-1:1000, IHC:1:50-1:100,
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- Supplied at 1.0 mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C,-80 °C
- Stockage commentaire
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- Antigène
- SMC1A (Structural Maintenance of Chromosomes 1A (SMC1A))
- Autre désignation
- SMC1A (SMC1A Produits)
- Synonymes
- anticorps CDLS2, anticorps DXS423E, anticorps SB1.8, anticorps SMC1, anticorps SMC1L1, anticorps SMC1alpha, anticorps SMCB, anticorps SMC-1A, anticorps NV15570, anticorps 5830426I24Rik, anticorps Sb1.8, anticorps Smc1, anticorps Smc1alpha, anticorps Smc1l1, anticorps Smcb, anticorps mKIAA0178, anticorps smc1, anticorps smc1a, anticorps smc1l1, anticorps xSMC1, anticorps smc1aa, anticorps structural maintenance of chromosomes 1A, anticorps structural maintenance of chromosomes 1A b, anticorps structural maintenance of chromosomes 1A L homeolog, anticorps SMC1A, anticorps smc1a, anticorps Smc1a, anticorps smc1ab, anticorps smc1a.L
- Sujet
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Background: Involved in chromosome cohesion during cell cycle and in DNA repair. Central component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. Involved in DNA repair via its interaction with BRCA1 and its related phosphorylation by ATM, or via its phosphorylation by ATR. Works as a downstream effector both in the ATM/NBS1 branch and in the ATR/MSH2 branch of S-phase checkpoint.
Yang XM. et al. (2004) Mol Cell Biol. 24(12): 5290-5303.
Kim ST. et al. (2002) Genes Dev. 16(5): 560-570.
Revenkova E.et al. (2001) Mol Cell Biol. 21(20): 6984-6998Aliases: Chromosome segregation protein SmcB antibody, DXS423E antibody, KIAA0178 antibody, MGC138332 antibody, Sb1.8 antibody, Segregation of mitotic chromosomes 1 antibody, SMC protein 1A antibody, SMC-1-alpha antibody, SMC-1A antibody, SMC1 (structural maintenance of chromosomes 1 yeast) like 1 antibody, SMC1 antibody, SMC1 structural maintenance of chromosomes 1 like 1 antibody, SMC1A antibody, SMC1A_HUMAN antibody, SMC1alpha antibody, SMC1L1 antibody, SMCB antibody, Structural maintenance of chromosomes 1A antibody, Structural maintenance of chromosomes protein 1A antibody
- UniProt
- Q14683
- Pathways
- Stem Cell Maintenance
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