IKK alpha anticorps (pThr23)

N° du produit ABIN7138810

Détail du produit anti-IKK alpha anticorps

Antigène: IKK alpha (CHUK) (conserved Helix-Loop-Helix Ubiquitous Kinase (CHUK))

Épitope: pThr23

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp IKK alpha est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Réactivité croisée: Humain, Souris, Rat

Purification: Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

Immunogène: Peptide sequence around phosphorylation site of threonine 23 (L-G-T(p)-G-G) derived from Human IKK a.

Isotype: IgG

Information d'application

Indications d'application: WB:1:500-1:1000, IHC:1:50-1:100,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Supplied at 1.0 mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur IKK alpha

Antigène: IKK alpha (CHUK) (conserved Helix-Loop-Helix Ubiquitous Kinase (CHUK))

Autre désignation: CHUK (CHUK Produits)

Synonymes: anticorps ikk, anticorps ikk1, anticorps ikka, anticorps ikkalpha, anticorps CHUK, anticorps IKBKA, anticorps IKK-alpha, anticorps IKK1, anticorps IKKA, anticorps NFKBIKA, anticorps TCF16, anticorps AI256658, anticorps Chuk1, anticorps Fbx24, anticorps Fbxo24, anticorps Ikka, anticorps zgc:56539, anticorps conserved helix-loop-helix ubiquitous kinase S homeolog, anticorps conserved helix-loop-helix ubiquitous kinase, anticorps chuk.S, anticorps CHUK, anticorps Chuk, anticorps chuk

Sujet:

Background:

Acts as part of the IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. As part of the non-canonical pathway of NF-kappa-B activation, the MAP3K14-activated CHUK/IKKA homodimer phosphorylates NFKB2/p100 associated with RelB, inducing its proteolytic processing to NFKB2/p52 and the formation of NF-kappa-B RelB-p52 complexes. Also phosphorylates NCOA3. Phosphorylates 'Ser-10' of histone H3 at NF-kappa-B-regulated promoters during inflammatory responses triggered by cytokines.

Yuan ZQ, et al.(2002) J Biol Chem, 277(33): 29973-82.
Ozes ON, et al. (1999) Nature, 401(6748): 82-5.

Aliases: chuk antibody, CHUK1 antibody, Conserved Helix Loop Helix Ubiquitous Kinase antibody, Conserved helix loop ubiquitous kinase antibody, Conserved helix-loop-helix ubiquitous kinase antibody, I Kappa B Kinase 1 antibody, I Kappa B Kinase Alpha antibody, I-kappa-B kinase 1 antibody, I-kappa-B kinase alpha antibody, IkappaB kinase antibody, IkB kinase alpha subunit antibody, IkBKA antibody, IKK 1 antibody, IKK A antibody, IKK a kinase antibody, IKK-A antibody, IKK-alpha antibody, IKK1 antibody, IKKA antibody, IKKA_HUMAN antibody, Inhibitor Of Kappa Light Polypeptide Gene Enhancer In B Cells antibody, Inhibitor Of Nuclear Factor Kappa B Kinase Alpha Subunit antibody, Inhibitor of nuclear factor kappa-B kinase subunit alpha antibody, NFKBIKA antibody, Nuclear Factor Kappa B Inhibitor Kinase Alpha antibody, Nuclear factor NF kappa B inhibitor kinase alpha antibody, Nuclear factor NF-kappa-B inhibitor kinase alpha antibody, Nuclear factor NFkappaB inhibitor kinase alpha antibody, Nuclear Factor Of Kappa Light Chain Gene Enhancer In B Cells Inhibitor antibody, TCF-16 antibody, TCF16 antibody, Transcription factor 16 antibody

UniProt: O15111

Pathways: Signalisation PI3K-Akt, Signalisation NF-kappaB, Signalisation RTK, TCR Signaling, Signalisation TLR, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Hepatitis C, Toll-Like Receptors Cascades, BCR Signaling, Ubiquitin Proteasome Pathway, S100 Proteins