PIK3R1/PIK3R3 anticorps (pTyr467)

N° du produit ABIN7139011

Détail du produit anti-PIK3R1/PIK3R3 anticorps

Antigène: PIK3R1/PIK3R3 (PIK3R3A) (Phosphoinositide-3-Kinase, Regulatory Subunit 3a (Gamma) (PIK3R3A))

Épitope: pTyr467

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PIK3R1/PIK3R3 est non-conjugé

Application: ELISA, Western Blotting (WB)

Réactivité croisée: Humain, Souris, Rat

Purification: Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

Immunogène: Peptide sequence around phosphorylation site of tyrosine 467 (L-Y(p)-E-E-Y) derived from Human PI3 Kinase p85/p55.

Isotype: IgG

Information d'application

Indications d'application: WB:1:500-1:1000,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Supplied at 1.0 mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur PIK3R1/PIK3R3

Antigène: PIK3R1/PIK3R3 (PIK3R3A) (Phosphoinositide-3-Kinase, Regulatory Subunit 3a (Gamma) (PIK3R3A))

Autre désignation: PIK3R1/PIK3R3 (PIK3R3A Produits)

Synonymes: anticorps wu:fb16a12, anticorps wu:fk56b03, anticorps zgc:73230, anticorps phosphoinositide-3-kinase, regulatory subunit 3a (gamma), anticorps pik3r3a

Sujet:

Background:

Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Binds to activated (phosphorylated) protein-tyrosine kinases through its SH2 domain and regulates their kinase activity. During insulin stimulation, it also binds to IRS-1./Binds to activated (phosphorylated) protein-tyrosine kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane.

Stoyanov, B. et al. (1995) Science 269, 690-3.
Simpson, L. and Parsons, R. (2001) Exp Cell Res 264, 29-41.
Neri, L.M. et al. (2002) Biochim Biophys Acta 1584, 73-80.

Aliases: p85, AGM7, p85-ALPHA, p55, p55-GAMMA

UniProt: P27986, Q92569