B-Cell Linker anticorps (pTyr84)

N° du produit ABIN7139078

Détail du produit anti-B-Cell Linker anticorps

Antigène: B-Cell Linker (BLNK)

Épitope: pTyr84

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp B-Cell Linker est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Réactivité croisée: Humain, Souris, Rat

Purification: Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

Immunogène: Peptide sequence around phosphorylation site of tyrosine 84 (E-M-Y(p)-V-M) derived from Human BLNK.

Isotype: IgG

Information d'application

Indications d'application: WB:1:500-1:3000, IHC:1:50-1:100,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur B-Cell Linker

Antigène: B-Cell Linker (BLNK)

Autre désignation: BLNK (BLNK Produits)

Synonymes: anticorps BLNK, anticorps blnk, anticorps MGC147045, anticorps BASH, anticorps Bca, anticorps Ly-57, anticorps Ly57, anticorps Lyw-57, anticorps SLP-65, anticorps AGM4, anticorps BLNK-S, anticorps LY57, anticorps SLP65, anticorps bca, anticorps B-cell linker, anticorps B cell linker, anticorps BLNK, anticorps blnk, anticorps Blnk

Sujet:

Background: Functions as a central linker protein, downstream of the B-cell receptor (BCR), bridging the SYK kinase to a multitude of signaling pathways and regulating biological outcomes of B-cell function and development. Plays a role in the activation of ERK/EPHB2, MAP kinase p38 and JNK. Modulates AP1 activation. Important for the activation of NF-kappa-B and NFAT. Plays an important role in BCR-mediated PLCG1 and PLCG2 activation and Ca2+ mobilization and is required for trafficking of the BCR to late endosomes. However, does not seem to be required for pre-BCR-mediated activation of MAP kinase and phosphatidyl-inositol 3 (PI3) kinase signaling. May be required for the RAC1-JNK pathway. Plays a critical role in orchestrating the pro-B cell to pre-B cell transition. May play an important role in BCR-induced B-cell apoptosis.

Aliases: AGM4 antibody, B cell adapter containing SH2 domain protein antibody, B cell adapter containing Src homology 2 domain protein antibody, B cell adaptor containing SH2 domain antibody, B cell linker antibody, B cell linker protein antibody, B cell-specific adaptor protein antibody, B-cell activation antibody, B-cell adapter containing a SH2 domain protein antibody, B-cell adapter containing a Src homology 2 domain protein antibody, B-cell linker protein antibody, BASH antibody, Bca antibody, BLNK antibody, BLNK s antibody, BLNK_HUMAN antibody, Cytoplasmic adapter protein antibody, Ly 57 antibody, Ly57 antibody, Lymphocyte antigen 57 antibody, Lyw 57 antibody, Lyw57 antibody, MGC111051 antibody, SH2 domain-containing leukocyte protein, 65-KD antibody, SLP 65 antibody, SLP-65 antibody, SLP65 antibody, Src homology [SH2] domain-containing leukocyte protein of 65 kD antibody, Src homology 2 domain containing leukocyte protein of 65 kDa antibody, Src homology 2 domain-containing leukocyte protein of 65 kDa antibody

UniProt: Q8WV28

Pathways: BCR Signaling