Sestrin 2 anticorps (AA 42-61) (Biotin)

N° du produit ABIN7140136

Détail du produit anti-Sestrin 2 anticorps (Biotin)

Antigène: Sestrin 2 (SESN2)

Épitope: AA 42-61

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Sestrin 2 est conjugé à/à la Biotin

Application: ELISA

Réactivité croisée: Humain

Purification: >95%, Protein G purified

Immunogène: Peptide sequence from Human Sestrin-2 protein (42-61AA)

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur Sestrin 2

Antigène: Sestrin 2 (SESN2)

Autre désignation: SESN2 (SESN2 Produits)

Synonymes: anticorps HI95, anticorps SES2, anticorps SEST2, anticorps Ses2, anticorps MGC81239, anticorps SESN2, anticorps sestrin-2, anticorps hi95, anticorps ses2, anticorps sest2, anticorps Sestrin-2, anticorps RGD1566319, anticorps sestrin 2, anticorps sestrin 2 L homeolog, anticorps SESN2, anticorps Sesn2, anticorps sesn2.L, anticorps sesn2

Sujet:

Background: Functions as an intracellular leucine sensor that negatively regulates the TORC1 signaling pathway through the GATOR complex. In absence of leucine, binds the GATOR subcomplex GATOR2 and prevents TORC1 signaling (PubMed:18692468, PubMed:25263562, PubMed:25457612, PubMed:26449471, PubMed:26612684, PubMed:26586190). Binding of leucine to SESN2 disrupts its interaction with GATOR2 thereby activating the TORC1 signaling pathway (PubMed:26449471, PubMed:26586190). This stress-inducible metabolic regulator also plays a role in protection against oxidative and genotoxic stresses. May negatively regulate protein translation in response to endoplasmic reticulum stress, via TORC1 (PubMed:24947615). May positively regulate the transcription by NFE2L2 of genes involved in the response to oxidative stress by facilitating the SQSTM1-mediated autophagic degradation of KEAP1 (PubMed:23274085). May also mediate TP53 inhibition of TORC1 signaling upon genotoxic stress (PubMed:18692468). Has an alkylhydroperoxide reductase activity born by the N-terminal domain of the protein (PubMed:26612684). Was originally reported to contribute to oxidative stress resistance by reducing PRDX1 (PubMed:15105503). However, this could not be confirmed (PubMed:19113821).

Aliases: DKFZp761M0212 antibody, DKFZp761M02121 antibody, Hi95 antibody, Hypoxia induced gene 95 antibody, MGC11758 antibody, OTTHUMP00000003641 antibody, OTTMUSP00000010184 antibody, RP23 63D8.3 antibody, SES2 antibody, SESN 2 antibody, SESN2 antibody, SESN2_HUMAN antibody, SEST2 antibody, Sestrin 2 antibody, Sestrin-2 antibody

UniProt: P58004