IFNK anticorps (AA 24-195)

N° du produit ABIN7140830

Détail du produit anti-IFNK anticorps

Antigène: IFNK (Interferon, kappa (IFNK))

Épitope: AA 24-195

Reactivité: Boeuf (Vache)

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp IFNK est non-conjugé

Application: ELISA

Réactivité croisée: Boeuf (Vache)

Purification: >95%, Protein G purified

Immunogène: Recombinant Bovine Interferon tau-1 protein (24-195AA)

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur IFNK

Antigène: IFNK (Interferon, kappa (IFNK))

Autre désignation: IFNT1 (IFNK Produits)

Synonymes: anticorps IFNK, anticorps IFNT1, anticorps INFE1, anticorps RP11-27J8.1, anticorps interferon kappa, anticorps IFNK, anticorps Ifnk

Sujet:

Background: Paracrine hormone primarily responsible for maternal recognition of pregnancy. Interacts with endometrial receptors, probably type I interferon receptors, and blocks estrogen receptor expression, preventing the estrogen-induced increase in oxytocin receptor expression in the endometrium. This results in the suppression of the pulsatile endometrial release of the luteolytic hormone prostaglandin F2-alpha, hindering the regression of the corpus luteum (luteolysis) and therefore a return to ovarian cyclicity. This, and a possible direct effect of IFN-tau on prostaglandin synthesis, leads in turn to continued ovarian progesterone secretion, which stimulates the secretion by the endometrium of the nutrients required for the growth of the conceptus. In summary, displays particularly high antiviral and antiproliferative potency concurrently with particular weak cytotoxicity, high antiluteolytic activity and immunomodulatory properties. In contrast with other IFNs, IFN-tau is not virally inducible.

Aliases: IFNT1 antibody, Interferon tau-1 antibody, IFN-tau-1 antibody, Antiluteolysin antibody, Trophoblast antiluteolytic protein antibody, Trophoblast protein 1 antibody, TP-1 antibody, Trophoblastin antibody

UniProt: P15696