OAS1 anticorps (AA 296-395)

N° du produit ABIN7142170

Détail du produit anti-OAS1 anticorps

Antigène: OAS1 (2',5'-Oligoadenylate Synthetase 1, 40/46kDa (OAS1))

Épitope: AA 296-395

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp OAS1 est non-conjugé

Application: Immunohistochemistry (IHC), ELISA

Réactivité croisée: Humain

Purification: >95%, Protein G purified

Immunogène: Recombinant Human 2\'-5\'-oligoadenylate synthase 1 protein (296-395AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: IHC:1:20-1:200,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur OAS1

Antigène: OAS1 (2',5'-Oligoadenylate Synthetase 1, 40/46kDa (OAS1))

Autre désignation: OAS1 (OAS1 Produits)

Synonymes: anticorps OAS1, anticorps IFI-4, anticorps OIAS, anticorps OIASI, anticorps L3, anticorps Pp2a2, anticorps 2',5'-oligoadenylate synthetase 1, anticorps 2'-5'-oligoadenylate synthetase 1, anticorps 2'-5' oligoadenylate synthetase 1A, anticorps protein phosphatase 2 catalytic subunit beta, anticorps OAS1, anticorps Oas1a, anticorps Ppp2cb, anticorps Oas1

Sujet:

Background: Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes higher oligomers of 2\'-5\'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L. The secreted form displays antiviral effect against vesicular stomatitis virus (VSV), herpes simplex virus type 2 (HSV-2), and encephalomyocarditis virus (EMCV) and stimulates the alternative antiviral pathway independent of RNase L.

Aliases: (2 5')oligo(A) synthetase 1 antibody, (2-5'')oligo(A) synthase 1 antibody, 2 5 Oligoadenylate Synthetase 1 antibody, 2 5' oligo A synthase 1 antibody, 2 5' oligo A synthetase 1 antibody, 2 5A synthase 1 antibody, 2 5A synthetase 1 antibody, 2' 5' oligo A synthetase 1 antibody, 2' 5' oligoadenylate synthetase 1 40/46 kDa antibody, 2' 5' oligoadenylate synthetase 1 antibody, 2' 5' oligoisoadenylate synthetase 1 antibody, 2''-5''-oligoadenylate synthase 1 antibody, 2'5' oligo A synthetase 1 antibody, 2'5' oligoadenylate synthetase 1 antibody, 2'5' oligoisoadenylate synthetase 1 antibody, 2-5A synthase 1 antibody, E18/E16 antibody, IFI 4 antibody, IFI4 antibody, OAS 1 antibody, OAS1 antibody, OAS1_HUMAN antibody, OIAS antibody, OIASI antibody, p46/p42 OAS antibody

UniProt: P00973

Pathways: Hepatitis C