PSMD1 anticorps (Regulatory Subunit 10) (FITC)
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- Antigène Voir toutes PSMD1 Anticorps
- PSMD1 (Proteasome (Prosome, Macropain) 26S Subunit, Non-ATPase, 1 (PSMD1))
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Épitope
- AA 1-226, Regulatory Subunit 10
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Reactivité
- Humain
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp PSMD1 est conjugé à/à la FITC
- Application
- Veuillez nous consulter SVP
- Réactivité croisée
- Humain
- Purification
- >95%, Protein G purified
- Immunogène
- Recombinant Human 26S proteasome non-ATPase regulatory subunit 10 protein (1-226AA)
- Isotype
- IgG
- Top Product
- Discover our top product PSMD1 Anticorps primaire
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- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4 - Agent conservateur
- ProClin
- Précaution d'utilisation
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C,-80 °C
- Stockage commentaire
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- Antigène
- PSMD1 (Proteasome (Prosome, Macropain) 26S Subunit, Non-ATPase, 1 (PSMD1))
- Autre désignation
- PSMD1 (PSMD1 Produits)
- Synonymes
- anticorps P112, anticorps Rpn2, anticorps S1, anticorps 2410026J11Rik, anticorps zgc:55818, anticorps psmd1, anticorps proteasome 26S subunit, non-ATPase 1, anticorps proteasome (prosome, macropain) 26S subunit, non-ATPase, 1, anticorps proteasome 26S subunit, non-ATPase 1 L homeolog, anticorps PSMD1, anticorps Psmd1, anticorps psmd1, anticorps psmd1.L
- Sujet
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Background: Acts as a chaperone during the assembly of the 26S proteasome, specifically of the PA700/19S regulatory complex (RC). In the initial step of the base subcomplex assembly is part of an intermediate PSMD10:PSMC4:PSMC5:PAAF1 module which probably assembles with a PSMD5:PSMC2:PSMC1:PSMD2 module. Independently of the proteasome, regulates EGF-induced AKT activation through inhibition of the RHOA/ROCK/PTEN pahway, leading to prolonged AKT activation. Plays an important role in RAS-induced tumorigenesis. Acts as an proto-oncoprotein by being involved in negative regulation of tumor suppressors RB1 and p53/TP53. Overexpression is leading to phosphorylation of RB1 and proteasomal degradation of RB1. Regulates CDK4-mediated phosphorylation of RB1 by competing with CDKN2A for binding with CDK4. Facilitates binding of MDM2 to p53/TP53 and the mono- and polyubiquitination of p53/TP53 by MDM2 suggesting a function in targeting the TP53:MDM2 complex to the 26S proteasome. Involved in p53-independent apoptosis. Involved in regulation of NF-kappa-B by retaining it in the cytoplasm. Binds to the NF-kappa-B component RELA and accelerates its XPO1/CRM1-mediated nuclear export.
Aliases: 26S proteasome non-ATPase regulatory subunit 10 antibody, 26S proteasome regulatory subunit p28 antibody, Ankyrin repeat protein antibody, dJ889N15.2 antibody, Gankyrin antibody, Hepatocellular carcinoma-associated protein p28 II antibody, p28 antibody, p28(GANK) antibody, Proteasome (prosome, macropain) 26S subunit, non ATPase, 10 antibody, Proteasome 26S S10 antibody, PSD10_HUMAN antibody, Psmd10 antibody
- UniProt
- O75832
- Pathways
- Mitotic G1-G1/S Phases, DNA Replication, Synthesis of DNA, Ubiquitin Proteasome Pathway
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