AGRN anticorps (AA 968-1130) (FITC)

N° du produit ABIN7143603

Détail du produit anti-AGRN anticorps (FITC)

Antigène: AGRN (Agrin (AGRN))

Épitope: AA 968-1130

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp AGRN est conjugé à/à la FITC

Application: Veuillez nous consulter SVP

Réactivité croisée: Humain

Purification: >95%, Protein G purified

Immunogène: Recombinant Human Agrin protein (968-1130AA)

Isotype: IgG

Information d'application

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur AGRN

Antigène: AGRN (Agrin (AGRN))

Autre désignation: AGRN (AGRN Produits)

Synonymes: anticorps AGRIN, anticorps agrn, anticorps wu:fb57e07, anticorps Agrin, anticorps nmf380, anticorps AGR, anticorps HSPG, anticorps agrin, anticorps LOC465392, anticorps agrn, anticorps AGRN, anticorps Agrn

Sujet:

Background: Isoform 1: heparan sulfate basal lamina glycoprotein that plays a central role in the formation and the maintenance of the neuromuscular junction (NMJ) and directs key events in postsynaptic differentiation. Component of the AGRN-LRP4 receptor complex that induces the phosphorylation and activation of MUSK. The activation of MUSK in myotubes induces the formation of NMJ by regulating different processes including the transcription of specific genes and the clustering of AChR in the postsynaptic membrane. Calcium ions are required for maximal AChR clustering. AGRN function in neurons is highly regulated by alternative splicing, glycan binding and proteolytic processing. Modulates calcium ion homeostasis in neurons, specifically by inducing an increase in cytoplasmic calcium ions. Functions differentially in the central nervous system (CNS) by inhibiting the alpha(3)-subtype of Na+/K+-ATPase and evoking depolarization at CNS synapses. This secreted isoform forms a bridge, after release from motor neurons, to basal lamina through binding laminin via the NtA domain.

Aliases: AGRIN antibody, Agrin C-terminal 22 kDa fragment antibody, Agrin proteoglycan antibody, AGRIN_HUMAN antibody, Agrn antibody, C22 antibody, C90 antibody, FLJ45064 antibody, OTTHUMP00000044043 antibody

UniProt: O00468

Pathways: Glycosaminoglycan Metabolic Process, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development